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MRCPCH Part 2 > Oncology > Flashcards

Oncology Flashcards

1
Q

Birbeck’s granules

A

Langerhans’ cell histiocytosis

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2
Q

Which are the small round cell tumours

A

Rhabdomyosarcoma, neuroblastoma, Ewing’s sarcoma

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3
Q

Side effects of anthracyclines (doxorubicin and daunorubicin)

A

Cardiotoxicity

Myelosuppression

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4
Q

Side effects of bleomycin

A

Pulmonary fibrosis

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5
Q

Side effects of cyclophosphamide

A

Cystitis, myelosuppression

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6
Q

Side effects of vincristine

A

Neuropathy

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7
Q

Side effects of cytosine arabinoside

A

Cerebellar toxicity

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8
Q

Side effects of methotrexate

A

Mucositis, pulmonary and hepatotoxicity, myelosuppression

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9
Q

Side effects of L-asparaginase and doxorubicin

A

Encephalopathy
DIC
Cardiomyopathy

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10
Q

Cells with ‘owl eye’ appearance

A

Reed Steinberg cells = Hodgkin’s lymphoma

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11
Q

Most likely diagnosis with painless lymphadenopathy, raised ESR, eosinophilia

A

Hodgkin’s lymphoma

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12
Q

Retinoblastoma mutation

A

Rb1 mutation on 13q

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13
Q

Location of MEN1 gene

A

11q13.1

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14
Q

HNPCC gene

A 
EPCAM gene
MSH1
MLH1
MSH6
PMS2
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15
Q

Neurofibromatosis type 1 gene

A

NF1 on 17q

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16
Q

Neurofibromatosis type 2 gene

A

NF2 gene on 22

17
Q

Associations with poor prognosis in Ewing’s sarcoma

A 
Male sex
Age >18 years
Elevated LDH
Anaemia
Poor response to chemo
Location of tumour: axial primary tumours are worse
18
Q

Poor prognostic indicator for neuroblastoma

A

N-myc amplification

1p deletion

19
Q

Mutation in Li-Fraumeni

A

p53

20
Q

Risk of which cancer in Li Fraumeni

A

Soft tissue sarcomas

21
Q

Cause of WAGR

A

11p13 deletion

22
Q

What is WAGR syndrome?

A

Wilms’ tumour, aniridia, genitourinary malformation, retardation of development

23
Q

Features of Denys-Drash syndrome

A

Ambiguous genitalia
Glomerulosclerosis, which can cause hypertension
Up to 90% get Wilms’ tumour

24
Q

Where does medulloblastoma originate from?

A

Cerebellum

MRCPCH Part 2 (24 decks)

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