Opioids Flashcards Preview

Pharmacology Block 3 > Opioids > Flashcards

Flashcards in Opioids Deck (17):
1

Morphine

-Mu agonist. Activated by metabolism.
-Stimulation causes a decrease in release of cAMP. Disinhibition of efferents from PAG results in increased modulation of medullary 5HT and NE outputs.
-Supraspinal and spinal analgesia, sedation, inhibition of respiration, slowed GI transit, modulation of hormone release, miosis, euphoria.

2

Fentanyl

-Mu agonist, 100x as potent as morphine.

3

Methadone

-Mu agonist.
-Used in treatment of opioid abuse and chronic pain.

4

Meperidine

-Mu agonist. Forms toxic metabolite that can accumulate with frequent use.
-Lesser duration of analgesia.

5

Heroin

-Mu agonist. Activated by metabolism.
-Much more lipophilic than morphine (means more abuse potential).

6

Codeine

-Mu agonist.
-Not so great at alleviating pain. Much better antitussive.

7

Oxycodone

-Mu agonist.
-Moderate to severe pain.

8

Hydrocodone

-Opioid agonist.
-Moderate to severe pain, antitussive.

9

Hydromorphone

-Opioid agonist. 2-3 X as potent as morphine.

10

3 endogenous opioids:

1. B-endorphin (Mu)
2. Dynorphin (Kappa)
3. Enkephalin (Delta)

11

Nalbuphine

-Mu antagonist and kappa agonist.
-Stimulation results in supraspinal and spinal analgesia, psychotomimemtic effects, slowed GI transit.
-Can precipitate withdrawal in opioid-dependent patients since you're not getting the full morphine effect.

12

Buprenorphine

-Partial Mu agonist.
-A component of Suboxone (used to treat opioid dependency).

13

Naloxone

-Mu antagonist, used to treat opioid overdose.
-Component of Suboxone.

14

Naltrexone

-Mu antagonist, used to treat both opioid addiction and alcoholism.

15

Dextromethorphan

Only an antitussive.

16

Tramadol

-Weak Mu agonist. Also blocks NE and 5HT uptake.
-Used to treat mild to moderate pain.

17

Suboxone

-Buprenorphine + Naloxone.
-Used to treat opioid dependency.