Oral Antidiabetic Drugs 2

Question 1

Inhibit Glucagon secretion

Answer 1

Metformin

Question 2

Inhibit hepatic gluconeogenesis

Answer 2

Metformin

Question 3

Inhibit intestinal absorption of glucose

Answer 3

Metformin

Question 4

Increase Glucose uptake by skeletal muscle

Answer 4

Metformin

Question 5

Increase anaerobic glycolysis in peripheral tissues

Answer 5

Metformin

Question 6

Improve insulin sensitivity in periphery by increasing binding to its receptors

Answer 6

Metformin

Question 7

Used with obese diabetic patient

Answer 7

Metformin

Question 8

Can be used with sulphonylureas or insulin

Answer 8

Metformin

Question 9

No hypoglycemia

Answer 9

Metformin

Question 10

Git disturbances, lactic acidosis and long use of it cause decrease absorption of vitamin B 12
Are adverse effects of which drug

Answer 10

Metformin

Question 11

They activate nuclear PPAR receptors in adipose tissue skeletal muscle and liver

Answer 11

Thiazolidinediones (TZDs)

Question 12

That are insulin sensitizer by improving target cell response to insulin

Answer 12

Thiazolidinediones

Question 13

Increase no of glucose transporter

Answer 13

Thiazolidinediones

Question 14

Decrease hepatic glucose output

Answer 14

Thaizolidinediones

Question 15

Decrease free fatty acids levels

Answer 15

Thiazolidinediones

Question 16

Used as monotherapy or with sulfonylureas or metformin

Answer 16

Thiazolidinediones

Question 17

Effective in highly resistant patients

Answer 17

Thiazolidinediones

Question 18

It has slow onset and its effect appears after 1-2 month

Answer 18

Thiazolidinediones

Question 19

From its side effect is weight gain

Answer 19

Thaizolidinediones

Question 20

Increase risk of myocardial infarction and death

Answer 20

Thiazolidinediones

Question 21

From its side effect is peripheral edema

Answer 21

Thiazolidinediones

Question 22

From its side effect is hepatotoxicity

Answer 22

Thiazolidinediones

Question 23

From its side effect is
Osteoporosis and fracture

Answer 23

Thiazolidinediones

Question 24

Has teratogenic effect

Answer 24

Thaizolidinediones

Question 25

Increase in LDL

Answer 25

Thiazolidinediones

Question 26

Inhibit alpha glucosidase in the intestinal brush reduce glucose absorption

Answer 26

Alpha glucosidase inhibitors 👉🏻 Miglitol 👉🏻 Acarbose

Question 27

They decrease post prandial glucose

Answer 27

Miglitol and acarbose ( alpha glucosidase inhibitors)

Question 28

Used as monotherapy or combination with sulfonylureas, insulin and metformin

Answer 28

Alpha glucosidase inhibitors Miglitol Acarbose

Question 29

From it's side effects are Diarrhea Flatulence

Answer 29

Alpha glucosidase inhibitors Miglitol Acarbose

Question 30

Inhibit enzyme DPP-IV which is responsible for inactivation of incretin hormones such as glucagon like peptide1 (GLP-1)

Answer 30

Dipeptidyl peptidase -iv inhibitors ( DPP-IV) Sitagliptin Vildagliptin Saxagliptin

Question 31

Increase release of insulin in response to meals

Answer 31

Dpp IV inhibitors Sitagliptin Saxagliptin Vildagliptin

Question 32

Decrease glucagon secretion

Answer 32

Sitagliptin Vildagliptin Saxagliptin

Question 33

Used as monotherapy or with metformin Thiazolidinediones Insulin

Answer 33

Sitagliptin Vildagliptin Saxagliptin

Question 34

From their adverse effects Headache Diarrhea Upper respiratory infection Pancreatitis Expensive

Answer 34

Sitagliptin Vildagliptin Saxagliptin

Question 35

From it's side effect is upper respiratory infection

Answer 35

Dpp IV inhibitors Sitagliptin Vildagliptin Saxagliptin

Question 36

From its side effects is pancreatitis

Answer 36

Sitagliptin Vildagliptin Saxagliptin

Question 37

They are expensive

Answer 37

Sitagliptin Vildagliptin Saxagliptin

Question 38

Enhance glucose dependent insulin secretion

Answer 38

GLP-1 Exenatide Liraglutide

Question 39

Inhibit glucagon secretion

Answer 39

Exenatide Liraglutide Pramlintide

Question 40

Inhibit hepatic glucose production

Answer 40

Exenatide Liraglutide

Question 41

Slow gastric emptying

Answer 41

Exenatide Liraglutide

Question 42

Increases satiety resulting in less food intake

Answer 42

Exenatide Liraglutide

Question 43

Has short duration given twice before meals

Answer 43

Exenatide

Question 44

Has long duration given once daily

Answer 44

Liraglutide

Question 45

Causes Nausea Vomiting Diarrhea or constipation

Answer 45

Exenatide Liraglutide

Question 46

Delay gastric emptying

Answer 46

Pramlintide

Question 47

Synthetic amylin analogue

Answer 47

Pramlintide

Question 48

Promote satiety

Answer 48

Pramlintide

Question 49

Used as adjunct therapy with or without SFU AND MET T2DM in patients mealtime insulin

Answer 49

Pramlintide

Question 50

New class of oral drugs to treat type 2 DM

Answer 50

SGLT2 inhibitors Canagliflozin Dapagliflozin Empagliflozin

Question 51

They inhibit SGLT2 at PCT prevent reabsorption of glucose increase renal excretion of glucose in urine

Answer 51

Canagliflozin Dapagliflozin Empagliflozin

Question 52

Reduce blood glucose levels

Answer 52

Canagliflozin Dapagliflozin Empagliflozin

Question 53

From there side effects is Urinary tract effect and female genital infection

Answer 53

Canagliflozin Dapagliflozin Empagliflozin

Question 54

Induce hypotension and tiredness

Answer 54

Canagliflozin Dapagliflozin Empagliflozin