Oral (tablets) Flashcards Preview

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Flashcards in Oral (tablets) Deck (20)
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1

Advantages of tablet: (3)

easy to take and handle

precise dosing

cheap to mass produce with consistent quality

2

Disadvantages of tablet: (3)

difficult to reverse

slower onset of action

first pass metabolism

3

Disintegrating tablets are..

the most common type, swallowed and release drug in a relatively shortt time

can be uncoated or coated

4

Gastro-resistant tablets are...

delayed release tablets, resist the gastric fluid and to release the drug in the intestinal fluid

covered with a gastro-resistant coating

5

Modified-release tablets are...

coated or uncoated tablets that are designed to modify the rate, the place or the time at which the drugs are released

6

3 types of modified-release tablets:

Prolonged - released slowly at a constant rate

Delayed release - released some time after administration

Pulsatile release - released from the formulation in two or more pulses

7

Dispersible tablets vs orodispersible tablets

dispersible are dispersed in water before oral administration

orodispersible are placed in the mouth where they disperse rapidly before being swallowed

8

Effervescent tablets are...

uncoated tablets that are dissolved or dispersed in water before administration

weak acid and a carbonate which react in water to release co2

temporarily increases stomach pH, allows drug to enter the intestine faster for absorption

9

Sublingual tablets are placed..

placed under the tounge

10

Buccal tablets are placed..

placed on the side of the cheek

11

Lozenges and Pastilles...

usually for local effect in the oral cavity and the throat.

12

What's the most common technique for tablet manufacturing?

powder compression

13

3 stages of powder compression:

die filling
- powder flows down from a hopper into the die

tablet formation
- upper punch comes down into the die compressing the powder into tablet


tablet ejection
- lower punch rises to eject the tablet

14

2 types of tablet presses:

- single punch press
one die and one punches
200 tablets per minute


- rotary press
multiple sets of punches and dies
10,000 tablets per minute

15

Tablet Excipients
Filler (diluent)

added to increase the bulk volume of the powder and hence the tablet size

usually lactose is used - easily dissolves, good compactibility and pleasant taste

16

Tablet Excipients
Disintegrant

allows tablets to break up into small fragments when in contact with a liquid

starch most commonly used, swells in contact with water, disrupts the tablet to provide larger surface area during dissolution

17

Tablet Excipients
Binder (adhesive)

ensures granules and tablets can be formed with the required mechanical strength

can be added as powder or as solution

18

Tablet Excipients
Glidant

improves powder flowability by reducing cohesion between particles

19

Tablet Excipients
Lubricant

lowers friction between solid ingredients and machine wall

improves tablet formation and ejection

20

Tablet Excipients
Anti-adherent

reduces adhesion between powder and punch faces

prevents particles sticking to the punches