Flashcards in Oral (tablets) Deck (20)
Advantages of tablet: (3)
easy to take and handle
cheap to mass produce with consistent quality
Disadvantages of tablet: (3)
difficult to reverse
slower onset of action
first pass metabolism
Disintegrating tablets are..
the most common type, swallowed and release drug in a relatively shortt time
can be uncoated or coated
Gastro-resistant tablets are...
delayed release tablets, resist the gastric fluid and to release the drug in the intestinal fluid
covered with a gastro-resistant coating
Modified-release tablets are...
coated or uncoated tablets that are designed to modify the rate, the place or the time at which the drugs are released
3 types of modified-release tablets:
Prolonged - released slowly at a constant rate
Delayed release - released some time after administration
Pulsatile release - released from the formulation in two or more pulses
Dispersible tablets vs orodispersible tablets
dispersible are dispersed in water before oral administration
orodispersible are placed in the mouth where they disperse rapidly before being swallowed
Effervescent tablets are...
uncoated tablets that are dissolved or dispersed in water before administration
weak acid and a carbonate which react in water to release co2
temporarily increases stomach pH, allows drug to enter the intestine faster for absorption
Sublingual tablets are placed..
placed under the tounge
Buccal tablets are placed..
placed on the side of the cheek
Lozenges and Pastilles...
usually for local effect in the oral cavity and the throat.
What's the most common technique for tablet manufacturing?
3 stages of powder compression:
- powder flows down from a hopper into the die
- upper punch comes down into the die compressing the powder into tablet
- lower punch rises to eject the tablet
2 types of tablet presses:
- single punch press
one die and one punches
200 tablets per minute
- rotary press
multiple sets of punches and dies
10,000 tablets per minute
added to increase the bulk volume of the powder and hence the tablet size
usually lactose is used - easily dissolves, good compactibility and pleasant taste
allows tablets to break up into small fragments when in contact with a liquid
starch most commonly used, swells in contact with water, disrupts the tablet to provide larger surface area during dissolution
ensures granules and tablets can be formed with the required mechanical strength
can be added as powder or as solution
improves powder flowability by reducing cohesion between particles
lowers friction between solid ingredients and machine wall
improves tablet formation and ejection