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Pharmaceutics > Making A Medicine > Flashcards

Flashcards in Making A Medicine Deck (13)
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1

Drug

API

2

Medicine

Drug with the excipients

3

Excipient

Additional ingredients in the medicine

4

Formulation

Recipe for making a medicine

5

Pharmaceutics

The science of medicine design and manufacture

6

Drug properties include...

Molecular weight
solubility
pkA
log P
Stability
Melting point
solid form
particle shape

7

What 3 things are determined in the pre-formulation stage?

The physiochemical properties of the drug are determined

- stability and compatibility
- ease of formulation
- processability

8

Lipinski's rule of 5:

Molecular weight < 500 Da
Log P < 5
H-bond donors < 5
H-bond acceptors < 10

9

What affects solubility?

solvent and solute properties
temperature
pressure

10

The higher the logP...

the more lipophilic, lower aqueous solubility

11

Octanol is...

most commonly used organic solvent

12

Log P equation:

log (conc of octanol/ conc of water)

13

Drugs are more water soluble when...

ionised