Topical Preparations Flashcards Preview

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Flashcards in Topical Preparations Deck (15)
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1

Advantages of topical preparations: (4)

non invasive

easy dose withdrawal in case of adverse reactions

convenient

avoid hepatic first pass metabolism

2

Disadvantages of topical preparations: (3)

low skin permeability

skin irritation

difficult to determine dose accurately

3

How is dose administered via topicals?

Using fingertip unit

4

Ointment..

drug dissolved or dispersed in greasy base

can be difficult to spread, but promotes skin hydration

5

Creams..

semi-solid emulsion

longer residence time than lotion, excellent patient acceptability, easily washable

6

Gel..

viscous liquid, clear

forms a film on skin when dried

7

Lotion...

water based

high spreadibility, suitable on hairy skin, short residence time

primarily used for cleansing or disinfection

8

Foam...

dispersion of gas within a liquid

foam generated during use

9

Spray...

liquid droplets in gas - aerosol

without direct skin contact

rapid and even coverage of large surface area

10

Patch...

solid dosage form containing drug on an adhesive film

accurate dosing, protection of formulation

11

Cellular layers of the skin: (3)

epidermis
dermis
hypodermis

12

Factors affecting dermal drug transport:

age

disease - broken skin, thickened skin

drug properties

13

Midrodialysis

invasive treatment

where a semi permeable tube is inserted surgically below the skin

14

Tape stripping

stratum corneum progressively removed by tape

15

Shunt pathway

through hair follicles and sebaceous glands