Flashcards in Oral (Capsules) Deck (18)
Types of gelatin capsules:
hard capsules (2 piece - short piece and longer piece)
soft capsules (1 piece)
Raw materials of capsules: (4)
How is gelatin prepared?
by hydrolysis of collagen from connective tissues
from calf bones and pig skin
Gelatin production processeS: (2)
Acid and Alkali process
Advantages of gelatin (3)
non toxic and non irritiant
good film forming properties
soluble in biological fluids at body temp
Disadvantages of gelatin (2)
not suitable for vegetarians and vegans
What do colourants do?
Improve patient compliant and medicine identification
2 main types of colourants:
water soluble dyes
Storage of hard capsules?
moisture content between 13-16%
store at controlled temp and humidity so that its not too moist / too dry
Fillings of hard capsules must be... (3)
unreactive with shell
not leak out
be free from large amounts of moisture
Types of filling materials: (3)
- powders, pellets, granules
non aqueous liquids
Excipients used in powder filled capsules: (6)
How are hard capsules filled?
two halves of capsules are separated and an exact dose is spread inside, cap locked onto body
Capsule filling machines (3)
Advantages of soft capsules (3)
improves drug absorption - drug is already in solution
convenient, easy to use - no unpleasant taste
dose uniformity and precision
Types of soft gels (3)
oral soft gel (most common) e.g. cod liver oil
twist off/ suckable/ meltable
Soft gel composition: gelatine, plasticisers, water and additional.
What do the plasticisers do?
make the shell soft and pliable