Oral (Capsules) Flashcards Preview

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Flashcards in Oral (Capsules) Deck (18)
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1

Types of gelatin capsules:

hard capsules (2 piece - short piece and longer piece)

soft capsules (1 piece)

2

Raw materials of capsules: (4)

Gelatin
Water
Plasticisers
Colourants

3

How is gelatin prepared?

by hydrolysis of collagen from connective tissues

from calf bones and pig skin

4

Gelatin production processeS: (2)

Acid and Alkali process

5

Advantages of gelatin (3)

non toxic and non irritiant

good film forming properties

soluble in biological fluids at body temp

6

Disadvantages of gelatin (2)

gelatin allergy

not suitable for vegetarians and vegans

7

What do colourants do?

Improve patient compliant and medicine identification

8

2 main types of colourants:

water soluble dyes
insoluble pigments

9

Storage of hard capsules?

moisture content between 13-16%

store at controlled temp and humidity so that its not too moist / too dry

10

Fillings of hard capsules must be... (3)

unreactive with shell

not leak out

be free from large amounts of moisture

11

Types of filling materials: (3)

dry solids
- powders, pellets, granules


semisolids
- pastes

non aqueous liquids

12

Excipients used in powder filled capsules: (6)

diluents
lubricants
glidants
wetting agents
stabilisers
disintegrates

13

How are hard capsules filled?

two halves of capsules are separated and an exact dose is spread inside, cap locked onto body

14

Capsule filling machines (3)

hand operated
semi automatic
fully automatic

15

Advantages of soft capsules (3)

improves drug absorption - drug is already in solution

convenient, easy to use - no unpleasant taste

dose uniformity and precision

16

Types of soft gels (3)

oral soft gel (most common) e.g. cod liver oil

chewable

twist off/ suckable/ meltable

17

Soft gel composition: gelatine, plasticisers, water and additional.

What do the plasticisers do?

make the shell soft and pliable

18

Types of softgel fill matrices:

lipophilic liquids

hydrophilic liquids

self-emulsifying systems
- contains an oil and a surfactant which emulsify to form droplets when in contact with GI fluid - higher SA for diffusion of drug