organic acids Flashcards
1
Q
acidic and basic FGs can determine?
A
- solubility
- interaction with other drugs/excipients
- distribution in body
- pharmologival activity
-absorbtion into body
2
Q
acid and base lewis definition
A
acid = e- pair acceptor
base = e- pair donor
3
Q
acids and bases lowry definition
A
acid = proton donor
base = proton acceptor
4
Q
when analysing molecules for basic or acidic properties we look for:
A
FG with lone pairs (base)and FG with capacity to donate protons (acid)
5
Q
the higher the H30+ of a solution….
A
the more acidic it is and the lower the pH
6
Q
the strength of an acid is ….. and is expressed by…..
A
capability to shift equi to right and its acidity constant Ka
7
Q
low pKa =
A
stronger acid
8
Q
stronger acid the …..
A
lowers its conj base
9
Q
an acid will donate a proton to its conj base of any other acid with…
A
a larger pKa
-product must be moer stable than reactnants-
10
Q
what is the most important organic acid? why
A
COOH
- readily donates e- as it forms a stable conj base
