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Flashcards in osteoporosis Deck (20):

osteoporosis definiton

skeletal disorder characterized by compromised line strength predisposing to increased risk of fracture


what does bone strength comprise of

integration of density and quality


osteoclast origin

hematopoietic stem cells. similar to macrophages.


osteoblastic origin

mesenchymal stem cells


causes of diminished bone mass

failure to reach peak mass, or increased bone resorption and decreased bone formation


non modifiable risk factors for OP

female, advanced age, caucasian or asian, family history of osteoporosis, personal history of fracture, hyperthyroidism, early menopause, rheumatoid


why do women have an increased frequency of OP

lower peak bone mass by age 35, lighter, thinner bones, menopausal bone loss, pregnancy, lactation


modifiable risk factors for OP

tobacco use, sedentary life, caffeine use (tea is okay), low calcium/vitamin D, alcohol use, hormone deficiency, low BMI, elevated homocysteine,


primary OP

aging or decreased gonadal function, aging bone loss is slower than menopausal, 51-75


secondary OP

due to medications and diseases


diseases at risk for OP

hypogonadism, cushing, hyperparathyroidism, multiple myeloma, lymphoma, chronic liver and renal disease, malabsoprtion syndrome, paralyzed, RA, anorexia, athletic amenorrhea, DM, hemochromatosis, hyperporlactinemia, osteogenesis imperfecta, lupus, psoriatic arthritis, VIT D and calcium deficiency


medications risk

glucocorticoids, lithium, chemo, lupron, anticonvulsants, SSRIs, methotrexate, prolonged heparin, coumadin, immunosuppressants, aromatase inhibitors, excess thryoid hormone the shot, vitamin A and PPI


history major risks

fractures (esp the hip, vertebra or wrist, family with OP or fragility, menstrual or estrogen deficiency, lifestyleq


signs of vertebral fractures

back pain, loss of height, restrictive lung disease, reduced abdominal cavity, depression, anxiety, fear.


what to look for on exam

height and weight, spinal tenderness/deformities, dowagers hump, protuberant abdomen, assess for falling


what age for screening men and women

W 65, M 70; fracture after 50, younger postmenopausal women and men 50-69 with risk or adults with conditions,


what is the gold standard for screening

DXA on the vertebra, wrist, femoral neck.


when is there presence of OP

when the T score is less than or equal to -2.5


when is there i slow bone mass

when the T score is between -1 and -2.5


what is the t score

compares bone mineral density to average and expresses the difference as a standard deviation. calculated as bone mineral content per surface area, related to strength, and fracture risk.