p.27-40 Flashcards
(48 cards)
In the Diseases and Disorders that Associated with Hypothalamus and Pituitary gland, Most pituitary adenomas are _____?
Clonal in origin
This means that a single cell with altered growth control and feedback regulation.
Pituitary Adenoma
T/F:
In Pituitary Adenoma, it has at least 3 different syndromes caused by defined genetic mutations are known to raise significantly the incidence of pituitary tumor formation.
False
What are the types/kinds of Pituitary Adenoma?
- Prolactinoma
- Growth Hormone-secreting Adenoma
- Adrenocorticotropic Hormone secreting Pituitary Adenoma (Cushing Syndrome)
It is the most common anterior pituitary disorder caused by prolactin-secreting adenomas.
Hyperprolactinemia
These are the results in elevated prolactin levels:
Primary hypothyroidism
dopamine-receptor blocking drug therapy
In prolactinomas, they may also cotribute to physiologic hyperprolactinemia and distinguished from the pathogenic ones.
Pregnancy and lactation
How many % of pituitary adenomas found in autopsies of the prolactinomas?
40%
Most of the patients in prolactinomas had NO SYMPTOMS from _____ & ____ of unrelated causes.
microadenomas and died
It gives rise to the syndrome of GIGANTISM or ACROMEGALY depending on whether they develop before or after closure of EPIPHYSES.
Growth Hormone-secreting tumors
The clinical findings in gigantism and acromegaly reflect a combination of the insuline-like effects of growth hormone, what does insuline-like promoting?
Visceromegaly/ Enlargement of organs w/in the abdomen
The clinical findings in gigantism and acromegaly reflect a combination of the insuline-like effects of growth hormone and the counterregulatory effects, what does counterregulatory effects promoting?
Glucose intolerance
secretion of excess cortisol as a result of overproduction of by a pituitary adenoma is the most common cause of what syndrome?
Spontaneous Cushing Syndrome
It is the rapid progression of an ACTH-secreting pituitary adenoma?
Nelson Syndrome
It is often observed after _____ ________ to control the symptoms of cortisol excess.
Bilateral adrenalectomy
In ACTH-secreting pituitary adenoma, with the development of vigorous glucocorticoid substitution, What are the regimens?
Transsphenoidal pituitary surgery
radiation therapy
It refers to the loss/decrease of one or more pituitary hormones.
Hypopituitarism
It is the syndrome resulting from complete loss of all of the hormones secreted by pituitary gland.
Panhypopituitarism
What are the deficiencies that included in Hypopituitarism?
- Growth Hormone deficiency
- ACTH deficiency
- Gonadotropin (LH & FSH) deficiencies
- TSH deficiency
T/F:
The chemical hallmarks of hypopituitarism is low levels of pituitary hormones.
False (biochemical)
It is a syndrome of polyuria resulting from the inability to concentrate urine due to lack of vasopressin action and, therefore, increased urine output.
Diabetes insipidus
diseases in Diabetes insipidus:
•Diseases of the CNS (central diabetes insipidus)
•Diseases of the kidney (nephrogenic diabetes insipidus)
•Pregnancy
It is a Diabetes insipidus disease that affects the synthesis/secretion of vasopressin.
Diseases of CNS (Central diabetes insipidus)
It is a Diabetes insipidus disease that loss the kidney’s ability to respond to circulating vasopressin and incapable in retaining water.
Diseases of the Kidney (nephrogenic diabetes insipidus)
