P3 IMMUNOLOGY Flashcards

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1
Q

Identify the shown IF pattern

A

Coarse speckled pattern.

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2
Q

an antibody (generally IgM directed against immunoglobulin), commonly present in the sera of patients with rheumatoid arthritis

A

Rheumatoid factor

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3
Q

give an example of false positive

A

chronic inflammatory conditions
Chronic infectious diseases
subacute bacterial endocarditis
post vaccination
viral infections

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4
Q

an antibody against autoantigens which have been modified by citrullination through deimination of arginine to citrulline
present in about two-thirds of all RA patients

A

Anti-CCP antibodies

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5
Q

highly specific and sensitive marker for rheumatoid arthritis.

A

ANTI-CCP

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6
Q

if RF is positive what further test would you perform

A

anti-CCP

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7
Q

Identify the test
what does it detect

A

Nephelometry [Turbidimetry}
- detects serum levels of C3,C4

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8
Q

Identify the IF pattern shown

A

Mitochondrial (cytoplasmic) pattern.

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9
Q

Identify the IF pattern shown

A

Centromere pattern.

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10
Q

Identify the IF pattern shown

A

Nucleolar homogeneous pattern

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11
Q

Identify the IF pattern shown

A

Nuclear membranous (peripheral) pattern.

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12
Q

Identify the IF pattern shown

A

Nuclear membranous (peripheral) pattern.

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13
Q

INDIRECT IMMUNOFLUORESCENCE is usually used for

A

antibody (Ab) assays

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14
Q

DIRECT IMMUNOFLUORESCENCE is usually used for

A

antigen detection

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15
Q

Identify the test

A

Enzyme linked immunosorbent assay (ELISA)

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16
Q

Methodologies to detect Antinuclear antibodies (ANA)

A
  • ELISA
  • Indirect immunofluorescence
17
Q

Initial tests for RA / autoimmune diseases

A

ANA
C3-C4
RF

18
Q

Further tests for RA / autoimmune diseases

A

Anti-ds DNA
Anti-ENA
Anti-CCP

19
Q

cases that RF is positive but is not for RA

A

SLE patients
Sjogren’s syndrome
some patients with scleroderma or polymyositis