P5 PATHOLOGY

Question 1

chronic disease resulting from inappropriate mucosal immune activation

Answer 1

Inflammatory bowel disease

Question 2

IBD consists of

Answer 2

• ulcerative colitis
• crohn disease

Question 3

Distinction between the 2 types is based on

Answer 3

Affected sites
histology

Question 4

most common sites for crohn’s disease

Answer 4

terminal ileum , ileocecal valve , cecum

Question 5

gross appearance of crohn’s

Answer 5

skip lesions , linear snake like ulcerations
Thickened mesenteric fat/ creeping fat
Cobblestone appearance of mucosa

Question 6

Microscopic / activity features in crohn’s

Answer 6

cryptitis & crypt abscess

Question 7

Microscopic chronicity features in crohn’s

Answer 7

non-caseating granulomas
transmural inflammation , mucin depletion , paneth cell metaplasia

Question 8

Complications of crohn’s

Answer 8

Malabsorption syndrome
anal lesions , fistula , malignancy , hemorrhage

Question 9

most common sites for Ulcerative colitis

Answer 9

rectum and sigmoid colon , extends proximally to involve part or all of the colon

Question 10

incase of complete colon affected its termed as

Answer 10

pancolitis

Question 11

incase of extending to terminal ileum it is termed as

Answer 11

backwash ileitis

Question 12

gross appearance in ulcerative colitis

Answer 12

broad-based ulcers ,pseudopolyps
mucosal atrophy ,no mural thickening

Question 13

Microscopic activity features in ulcerative colitis

Answer 13

cryptitis and crypt abscess

Question 14

Microscopic chronicity features in ulcerative colitis

Answer 14

mucin depletion , paneth cell metaplasia
Inflammation limited to mucosa & superficial submucosa

Question 15

Complications of ulcerative colitis

Answer 15

toxic megacolon
colorectal cancer
Cirrhosis , hepatitis
hemorrhage leading to anaemia