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MSS - GI Exam 1 > Pancreas > Flashcards

Flashcards in Pancreas Deck (42)
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1

location of pancreas

retroperitoneal space
LV2
oblique/transverse in position

2

origin of pancreas?

endoderm

develops from ventral and dorsal pancreatic buds

pair of evaginations off of primitive gut tube

3

pancreatic head

includes uncinate process
attached to 2nd and 3rd portions of duodenum

4

function of pancreas

both exocrine and endocrine

only 1% is endocrine

5

blood supply to pancreas

gastroduodenal artery (branch of common hepatic)
-to pancreatic head

splits to posterior and anterior superior pancreaticoduodenal artery

anastomose with inferior pancreaticoduodenal artery

6

pancreatic neck

straddles SMV and portal vein

7

pancreatic body

longest segment of organ

8

location of pancreatic body

-

9

pancreatic tail

lies at level of TV12

may be injured during splenectomy

10

duct of santorini

accessory duct
drains superior portion of head and empties separately into duodenum

11

duct of wirsung

main duct
merges with common bile duct to ampulla of vater

12

why accessory duct?

because pancreas formed from two buds

13

arterial supply of pancreas

superior pancreaticoduodenal - from gastroduodenal

inferior pancreaticoduodenal - from superior mesenteric

both anastomose (anterior and posterior branches)

14

from splenic artery?

dorsal, great, caudal pancreatic arteries

15

venous drainage of pancreas

follows arterial supply
-anterior and posterior arcades drain head and body
-to SMV and then to portal vein

splenic vein drains body and tail - to portal vein

16

exocrine anatomy of pancreas?

secretory acini and ducts

acini - 20-40 secretory cells coalesce into sac like unit (cells secrete digestive enzymes)

ducts - tubular network delivers exocrine secretions to duodenum

17

acinar cells

secrete digestive enzymes
-packed in zymogen granules, released into acinar lumen

amylase, lipase, and trypsinogen

18

ductal cells

secretes water and electrolytes

centroacinar and intercalated duct cells
secrete bicarbonate

in larger ducts, some cells secrete mucins

19

digestive juice

alkaline fluid
-colorless, odorless, isosmotic

enzymes activated in duodenum by acidic environment

pH neutralizes gastric aid and buffers intestinal pH

20

endocrine pancreas anatomy

less than 2% of pancreatic cells
-islands of cells (islets of langerhans)

21

major cell types in islets of langerhans

alpha cells 25-35%
beta cells 55-65%
delta cells 5-15%
PP cells <2%

22

alpha cells

produce glucagon

23

beta cells

produce insulin and amylin

24

delta cells

produce somatostatin

25

PP cells

produce pancreatic polypeptide

26

minor cell types in islets of langerhans

delta-1
EC cells
epsilon cells

27

delta-1 cells

produce VIP
-also in exocrine acini and ductal epithelium

28

EC cells

produce secretin, motilin, and substance P

also in exocrine acini and ductal epithelium

29

epsilon cells

produce ghrelin

30

insulin

released in response to glucose
-promotes glucose uptake (liver, muscle, fat)