pancreas Flashcards Preview

GI > pancreas > Flashcards

Flashcards in pancreas Deck (25):
1

location

retroperitoneal
LV2

2

pancreas development

endodermal in origin
from ventral and dorsla pancreatic buds

3

head

flattened structure , 2-3 cm thick
includes uncinate process
attached to 2nd and 3rd portions of duodenum
gastroduodenal a defines border w/neck

4

endocrine function

only 1%, mostly exocrine
about 20% of blood supply to exocrine tissue

5

neck

2-3 cm in length
antero-superior surface supports pylorus
straddles SMV and PV

6

BODY

anterior surface seperated from stomach by lesser sac
posterior surface related to aorta, left adrenal, ledt renal vessels, upper 1/3 left kidney
splenic v embedded in posterior surface
inferior surface covered by transverse mesocolon

7

tail

short narrow
TV12
terminates at splenic hilum w/in splenophrenic lig
anteriorly related to splenic flexure of colon
may be injured during splenectomy (fistula)

8

main duct

duct of wirsung
length of pancreas
merges w/common bile duct at ampulla of vater
2-4mm diameter
20 secondary brr
higher ductal pressure prevents backflow

9

accesory duct

duct of santorini
drains superior portion of head and empties separately into duodenum

10

exocrine microanatomy

secretory acini and ducts- 98% of pancreatic mass
acini- 20-40 secretory cells coalesce into sac-like unit, secrete digestive enzymes

11

endocrine microanatomy

islets of langerhans
alpha cells
beta cells
delta cells
PP cells
minor: delta-1, EC, epsilon

12

alpha cells

25-35% of iselt cells
produce glucagon

13

beta cells

55-65% of islet cells
produce insulin, amylin

14

delta cells

5-15% of islet cells
produce somatostatin

15

PP cells

<2% of islet cells
produce pancreatic polypeptide

16

delta-1

1% of islet cells
produce VIP
also found in exocrine acini and ductal epithelium

17

EC cells

1% of islet cells
produce: secretin, motilin, substance P
also found in exocrine acini, ductal epithelium

18

epsilon cells

1% of islet cells
produce ghrelin

19

stimulatory inputs

glucose, amino acids, glucagon, GIP,CCK, sulfonylurea compounds, B-sympathetics

20

inhibitory inputs

somatostatin, amylin, pancreastatin, alpha-sympathetics

21

pancreatic polypeptide

stimulates gastric chief cells
inhibits bile secretion and intestinal motility
inhibits pancreatic enzymes and bicarb secretion

22

VIP

similar action of glucagon (hyperglycemic and glycogenolytic)
also affects secretory activity and gut motility
stimulates pancreatic exocrine secretion

23

secretin

acts locally
stimulates bicarb secretion and other pancreatic enzymes

24

ghrelin

stimulates appetite

25

blood entering islets

encounters beta cells first