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253-Green Patho > Pancreas > Flashcards

Flashcards in Pancreas Deck (16):
1

What is Acute pancreatitis

inflm of the pancreas

2

What is the most common cause of pancreatitis

Auto digestion (enzymes digesting str components of Pancreas)

3

Can pancreatitis be caused by an infection

Yes

4

Is the pancreas mainly exocrine or endocrine

exocrine (out to GI)

5

How serious is pancreatitis

Can be life threatening (Often self limiting, but very dangerous)

6

Etiology of Pancreatitis (5)

Alcohol abuse (~70%)
Gallstones
Idiopathic(~10%)
Others (Pancreatic trauma, drugs)

7

How and where are pancreatic enzymes activated

By bile in the duodenum

8

Basic pathology of autosuggestion

Impeded Bile flow -> premature activation of es -> Es cause damage

Proteins and lipids which are structural will be broken down by Es- auto digestion ->(inflm exudate) Necrosis and Hemorrhage of blood vessels in pancreas

9

How does alcohol effect autosuggestion

Alcohol increases pancreatic secretions (OH abuse)

Alcohol also constricts sphincter (of Oddi) leading to duodenum

Bile and secretion mix back up into pancreas

10

In what timeframe does pancreatitis MNFT

Acute onset (likely after large meal or night of drinking)

But it has likely been a festering problem fro some time

11

Objective MNFTS on physical

Severe abd pain ( Epigastric and Radiates to the back )

3rd spacing (lots) Into abd cavity (ascites)

12

Likely complication from 3rd spacing?

vascular collapse and shock possible from Hypovolemia (lots of and inflm)

13

MNFT apparent with lab work

Increased blood amylase and lipase. Es excreted by pancreas, provide marker when in blood

Lipase better because amylase is also produced in salivary gland. Lipase more specific Es to pancreas

14

Tx for mild

~ 1 week recovery (monitoring is key intervention)

NPO (limits bile production), pain fluids/electrolytes, correct metb abn (fix potential issue with insulin)

15

Tx for severe

ICU
o Third spacing- renal, circulatory, hepatobiliary support (underlying cause)
o IV opiates
o Sx (obstruction or hemorrhage)

16

Describe ducts system from pancreas

Main pancreatic duct joins the common bile duct at the hepatopancreatic ampulla (ampulla of vader, through major duodenal papilla (aka sphincter of do) into duodenum.

There a sphincter at end of pancreatic duct

Some people have an accessory pancreatic duct which also empties into duodenum