Flashcards in The Big "C" Deck (18):
Are primary or secondary malignancies more likely in the liver? Why?
it is heavily vascularized- portal, lymph, arteries
Describe Type 1 primary Liver cancer
TYPE 1- hepatocellular carcinoma (ie malig, not benigh)
-> ~ 90% of liver CA
-> origin in hepatocytes
What is hepatocelluar carcinoma etiology linked to?
Chronic liver disease (e.g. Hep C)
Environmental toxins (eg arsenic)
Why does viral etiology fro Liver cancer make sense?
Viral etiology makes since virus insert their DNA into host DNA (similar to mutation)
What makes identifying MNFTS of liver Cancer difficult?
MNFTS are masked by those of underlying liver disease
Tx for Liver cancer?
Poor prognosis (advanced stage by time of Dx)
-> Partial hepatectomy (early dx)
-> Chemo and radiation (palliative care may exclude)
Describe Type 2 Liver CA
-> Origin in bile duct epithelium
-> Women 20-30 on the pill
-> Can be Hepatocytes or Vascular
• TX- Sx and removal of hormone
oRelated to chronic inflm in the duct epithelium
• (Associated with snail parasite, water and cyst in bile duct causiong chronic inflm)
Describe type 2 etiology
-> Related to chronic inflm in the duct epithelium
-> Associated with snail parasite, water and cyst in bile duct causiong chronic inflm)
Secondary (Metastatic tumors) often come to the liver from...
What is the advantage of secondary tumors vs primary?
From colon, lung and breast
Liver is a likely destination... therefore you are watching for it.
MNFTS of secondary Liver CA
Hepatomegaly, ascites, abdm pain, Anorexia, fever and weight loss
Prognosis and tx of 2* Liver CA
Very poor prognosis (3-6months until death) Supportive and palliative tx
Who is at higher risk of developing pancreatic Cancer?
What is the prognosis?
One of the leading causes of death from CA
90% mortality in the first year
Etiology of pancreatic CA
Unclear, but theoris include:
smoking (major risk)
DM and Chronic pancreatitis
What is the most common type of pancreatic CA? Where does it occur?
Occurs in duct epithelium
What causes the MNFTS in pancreatic CA
What are they?
Mnfts d/t mass rather then reduced fx•
Jaundice, wt loss, abdm pain (classic mnfts)
How is Pancreatic CA diagnosed?
US and CT for Dx
Usually has already metastasized