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253-Green Patho > The Big "C" > Flashcards

Flashcards in The Big "C" Deck (18):
1

Are primary or secondary malignancies more likely in the liver? Why?

Secondary-

it is heavily vascularized- portal, lymph, arteries

2

Describe Type 1 primary Liver cancer

TYPE 1- hepatocellular carcinoma (ie malig, not benigh)
-> ~ 90% of liver CA
-> origin in hepatocytes

3

What is hepatocelluar carcinoma etiology linked to?

Chronic liver disease (e.g. Hep C)

Environmental toxins (eg arsenic)

4

Why does viral etiology fro Liver cancer make sense?

Viral etiology makes since virus insert their DNA into host DNA (similar to mutation)

5

What makes identifying MNFTS of liver Cancer difficult?

Insidious onset

MNFTS are masked by those of underlying liver disease

6

Tx for Liver cancer?

Poor prognosis (advanced stage by time of Dx)

-> Partial hepatectomy (early dx)
-> Chemo and radiation (palliative care may exclude)

7

Describe Type 2 Liver CA

Cholangiocarcinomas
-> Origin in bile duct epithelium
-> Women 20-30 on the pill
-> Can be Hepatocytes or Vascular
• TX- Sx and removal of hormone
oRelated to chronic inflm in the duct epithelium
• (Associated with snail parasite, water and cyst in bile duct causiong chronic inflm)

8

Describe type 2 etiology

-> Related to chronic inflm in the duct epithelium

-> Associated with snail parasite, water and cyst in bile duct causiong chronic inflm)

9

Secondary (Metastatic tumors) often come to the liver from...

What is the advantage of secondary tumors vs primary?

From colon, lung and breast

Liver is a likely destination... therefore you are watching for it.

10

MNFTS of secondary Liver CA

Hepatomegaly, ascites, abdm pain, Anorexia, fever and weight loss


11

Prognosis and tx of 2* Liver CA

Very poor prognosis (3-6months until death) Supportive and palliative tx

12

Who is at higher risk of developing pancreatic Cancer?

Men
Black people
Smoker

13

What is the prognosis?

One of the leading causes of death from CA

90% mortality in the first year

14

Etiology of pancreatic CA

Unclear, but theoris include:
smoking (major risk)
Alcohol
DM and Chronic pancreatitis
Age (>50yrs)
Poor diet

15

What is the most common type of pancreatic CA? Where does it occur?

90% adenocarcinomas

Occurs in duct epithelium

16

What causes the MNFTS in pancreatic CA

What are they?

Mnfts d/t mass rather then reduced fx•

Jaundice, wt loss, abdm pain (classic mnfts)

17

How is Pancreatic CA diagnosed?

US and CT for Dx

Usually has already metastasized

18

Tx for Panc CA

Pain control is the key
Sx (1*) a possibility even if it has metastatsized, but not good prognosis
Chemo not so successful, radiation might be provided, but it will be palliative