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Flashcards in Parkinson Deck (24):
1

What are features of Parkinsons?

tremor, muscular rigidity, akinesia, rest tremor, and gait and postural impairment.

2

What are the 2 sub-types of Parkinsons?

Tremor dominant
non-tremor dominant

3

What are non-motor features of Parkinsons?

Olfactory dysfunction
Cognitive Impairment
Psychiatric symptoms
Sleep disorders
Autonomic dysfunction
pain and fatigue

4

What are pyramidal disorders?

Pyramidal weakness
Spasticity

5

What are Hyperkinetic disorders?

Dystonia
Tics
myoclonus
Chorea
Tremor

6

What are Hypokinetic disorders?

Parkinonism
Parkinson's Disease

7

What brain changes are seen in Parkinson's?

Sections reveal loss of the normally dark pigment in the substantia nigra and locus coeruleus

8

What does the brainstem pigment loss correlate to?

Dopaminergic cell loss

9

What is a neurohistological hallmark of Parkinson's?

Lewy bodies

10

What drugs are good for Parkinson's symptom control?

Dopamine Agonist
Levodopa
monoamine oxydase type B inhibitors
Amantadine

11

What drugs can be effective fir tremor?

Anticholinergics
Trihexyphenidyl
Clozapine

12

What is a good treatment for bradykinesia?

Dopaminergic drugs

13

What is used to treat late stage dementia in Parkinson's?

Rivastigmine

14

What do surgical treatments target?

Subthalamic nucleus or globus pallidus internus

15

What is bradykinesia?

Slowness of movement with progressive loss of amplitude or speed

16

What is Hypomimia?

Decreased facial expession and eye blinking

17

What is Micrographia?

Progressively smaller handwriting

18

What test can be +ve in parkinson's?

Froment's maneuver (Ragidity increases in examined body segment by voluntary movement if other body parts)

19

What is Festination?

Very fast succession of steps and difficulties stopping

20

What are two dopamine function tests?

PET with floura-dopa
Dopamine Transporter (DAT) imaging with single-photon emission CT (DAT-SPECT)

21

Positive Levodopa challenge is also know as the what?

s.c. apomorphine challenge

22

What is Fragile X-tremor ataxia syndrome? (FXTAS)

Neuordegenerative disorder with an abnormal number of CGG repeats in the FMR1 gene in the premature range (55-200)

23

What is seen on MMR of FXTAS?

T2 hyperintensities in the middle cerebral peduncle (MCP sign)

24

What will children with FXTAS probably have?

Classical Fragile X syndrome