Parvovirus b19 in pregnancy

Question 1

What is Parvovirus in pregnancy (aetiology, RF)

Answer 1

Parvovirus b19 causes erythema infectiosum (fiths disease)- small dsDNA virus
Incubation 4-20 days, infective 10 weeks prior rash until 1 day after rash appear

in pregnancy - risk of transmission before 20W

transmit via blood or airborn

RF- children and susceptible adults
60% of adults over 20 are immune

Question 2

Sx of Parvovirus in pregnancy

Answer 2

In young child//MOTHER
Rash, malaise, fever, arthalgua, transient aplastic crisis
Rash - SLAPPED CHEEK apprearance
(infants also have coryza, headache)

Neonate/antepartum
B19 crosses placenta before 20W and destroys RBC -> hydrops fetalis (High mortality) or misscariage

Question 3

Ix and mx of Parvovirus in pregnancy

Answer 3

If exposed after 20w can more or less Ignore
IgM and IgG - if both neg, redo 1m, if either +ve -> serial USS
USS- foetal anomaly scan 4w after onset of illness, then serial scan 2w until 40w
Rubella serology too (present similar)

Mx -
Maternal/infant - self limiting
Intrauterine - Blood transfuse for foetal hydrops

complications - misscariage, foetal hydrops