Path Salivary Gland Disease self study Flashcards Preview

GI & Liver Fall 2013 CBD > Path Salivary Gland Disease self study > Flashcards

Flashcards in Path Salivary Gland Disease self study Deck (16):
1

Sialadenitis

inflammation of salivary glands (many etiologies)

2

Frequent infectious agent in sialadenitis

staph aureus

3

bacterial sialadenitis (location, signs)

parotid glands, painful & swollen, purulent discharge drains from duct

4

chronic sialadenitis cause

sialolith
episodic pain & swelling, usually at meals

5

Kuttner tumor

chronic sialadenitis involving submandibular gland, persistent enlargement

6

salivary gland tumors:
common?
most common location
benign or malignant?

uncommon (7% heent tumors)
80% involve parotid
70% benign. The smaller the gland, the more likely malignant

7

Submandibular gland frequency

11% of salivary gland tumors, 45% malignant

8

sublingual gland

rare, 90% malignant

9

Pleomorphic adenoma
(gross, epidemiology)

benign mixed tumor
most common type of salivary gland tumor (50%)
Mixture of 2 germ layers.
more common in females (60%)
middle aged (50)
slow growing painless, moveable, firm mass

10

pleomorphic adenoma (histology)

encapsulated
epithelial component in ductal/cystic formations
myoepithelial cells in myxoid or chondroid matrix

11

Tx of pleomorphic adenoma

surg. low recurrence. CN-VII posible damage

12

Warthin's tumor (gross, epidemiology)

papillary cystadenoma lymphomatosum

2nd most common, 60% males, age 60, smoking
slow groing painless mass. firm or fluctuant in tail of parotid. 17% bilateral

Generally not actually neoplastic. Polyclonal. Low recurrence rate

13

Warthin's tumor histology (histology)

1 cystic spaces lined by double layer of oncocytes (epithelial cells with granular eosinophilic cytoplasm)

2 prominent lymphoid stroma (german centers possible)

14

Mucoepidermoid carcinoma (gross, epidemiology)

uncommon (15%)
most common malignant tumor of salivary gland
highly variable behavior
middle age, slightly more females

parotid and minor glands of palate
Asymptomatic swelling. Sometimes interosseous

15

Mucoepidermoid carcinoma (histology)

mix of mucous and squamous cells. mucicarmine stain can show mucus.

grade important in prognosis

16

survival rates in high and low mucoepidermoid carcinoma

tx

high grade: 50%
low grade: 90%

radiation post-op. variable outcome; younger patients fare better.