Pharm Drugs affecting Salivary Flow Flashcards Preview

GI & Liver Fall 2013 CBD > Pharm Drugs affecting Salivary Flow > Flashcards

Flashcards in Pharm Drugs affecting Salivary Flow Deck (19):
1

cevimiline [Evoxac] indication & mechanism

xerostomia
M3>>M1 agonist

CI: asthma, closed angle glaucoma, iritis

2

pilocarpine [Pilocar] indication & mechanism

xerostomia
muscarinic agonist (nonselective)

CI: asthma, closed angle glaucoma, iritis

3

amifostine [Ethyol] indication & mechanism

xerostomia. radioprotectant for people undergoing XRT. preserves salivary function while protecting from radiation. Treatment of tumors still works.

free radical scavenger

4

6 drug classes that induce xerostomia

antihistamines
decongestants
antidepressants
antipsychotics
antihypertensives
anticholinergics

5

sjogren's

dry eyes & mouth. artificial tears & saliva. DMARDs

6

alpha-amylase

salival component. cuts up sugars, starches. neutral pH optimal.

7

lipase

acid pH optimum saliva component

8

4 functions of saliva

digestion
solubilization (taste)
lubrication
protection

9

organic materials in saliva

lysozyme (lyses bacteria)
lactoferrin (gobbles up free Fe)
IgA binding protein (takes IgA to the party)

10

Addison's Na & K?
Cushing's Na & K?

Na high, K low
Na low, K high

11

xerostomia

lack of saliva

12

what effects concentrations of ions in saliva?

flow rate. slower = less b/c more time to extract. KHCO3 excreted.

Isoosmotic at all rates

13

parotid saliva type

serous

14

submaxillary saliva type

serous > mucus

15

sublingual saliva type

mucus > serous

16

CN responsible for saliva

symp/parasymp stimulation?

CN VII & IX

sympathetic & parasympathetic both stimulate

17

how does saliva get stim by parasympathetics?

chorda tympani N, parasympathetics -> Ach -> IP3

18

cellular metabolism pathway to saliva?

cell metabolism, kallikrein, plasma protein, bradykinin, increased saliva

19

sympathetic stim of salivation

sympathetics -> T1-T3 -> superior symp ganglion -> norepi -> cAMP increased