Flashcards in Path IBD Deck (40):
2 major forms of IBD
Cigarette smoking effect on CD & UC
Appendectomy effect on CD & UC
high sanitation level in childhood effect on CD & UC
UC no effect
High intake of refined carbohydrates effect on CD & UC
UC no effect
description of UC and CD affected GI areas
UC always rectum, retrograde continuous spread
CD anywhere, including ilium and colon. big diversity
broad based ulcerations
toxic megacolon as potential sequelae
gross pathology of UC
hemorrhagic, edematous, mucosa with superficial ulceration, loss of folding pattern. pseuopolyps.
microscopic pathology of UC
inflammatory cells, superficial ulceration (mucosa +/- submucosa) crypt abscesses
UC (even when no necrosis)
granulomas in UC?
inflammatory cells in UC
lymphocytes, plasma cells, eosinophils, macrophages, but no granulomas
UC limited to rectum
rectal bleeding, pain, urgency, tenesmus
mildest form of UC
UC of rectum and sigmoid
bloody diarrhea, abdominal cramps, pain, tenesmus.
bloody diarrhea, abdominal cramps, pain, unintended weight loss.
all colon. bloody diarrhea, abdominal cramps, pain, fatigue
entire colon - pain, diarrhea, dehydration/shock, SIRS. Deep colonic injury
most sensitive test for free air (as in toxic megacolon with perforation)
What imaging for detail of mucosa?
barium contrast. CT is poor at this
any part of GI tract mouth to anus.
small bowel & proximal colon most common
peak at 20-29
aphthous ulcers association?
small intestine alone %
small intestine & colon %
colon alone %
small intestine alone 30%
small intestine & colon 40%
colon alone 30%
inflammatory cells in CD
neutrophils, lymphs, plasma cells, eosinophils, macrophages w/granulomas (35%)
extra-intestinal manifestations of IBD (9)
scleritis, episcleritis, uveitis
uric acid & oxalate stones
IBD risk factors for colorectal CA (6)
long term IBD
young age of onset IBD
backwash ileitis (UC)
family history of colorectal ca
hx of sclerosing cholangitis
etiology of CD & UC
CD - disordered response to intestinal bacteria
UC - autoimmune
creeping fat, bowel wall thickening