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GI & Liver Fall 2013 CBD > Path IBD > Flashcards

Flashcards in Path IBD Deck (40):
1

2 major forms of IBD

ulcerative colitis
Crohn's disease

2

Cigarette smoking effect on CD & UC

CD increased
UC decreased!

3

Appendectomy effect on CD & UC

CD increased
UC decreased

4

high sanitation level in childhood effect on CD & UC

CD increase
UC no effect

5

High intake of refined carbohydrates effect on CD & UC

CD increase
UC no effect

6

description of UC and CD affected GI areas

UC always rectum, retrograde continuous spread
CD anywhere, including ilium and colon. big diversity

7

broad based ulcerations

UC

8

skip lesions

CD

9

toxic megacolon as potential sequelae

UC

10

pseudopolyp

UC

11

bloody diarrhea

UC

12

gross pathology of UC

hemorrhagic, edematous, mucosa with superficial ulceration, loss of folding pattern. pseuopolyps.

13

microscopic pathology of UC

inflammatory cells, superficial ulceration (mucosa +/- submucosa) crypt abscesses

14

crypt abscess

UC (even when no necrosis)

15

granulomas in UC?

no

16

inflammatory cells in UC

lymphocytes, plasma cells, eosinophils, macrophages, but no granulomas

17

ulcerative proctitis

UC limited to rectum
rectal bleeding, pain, urgency, tenesmus

mildest form of UC

18

proctosigmoiditis

UC of rectum and sigmoid
bloody diarrhea, abdominal cramps, pain, tenesmus.

continuous

19

left-sided colitis

bloody diarrhea, abdominal cramps, pain, unintended weight loss.

continuous

20

pancolitis

all colon. bloody diarrhea, abdominal cramps, pain, fatigue

21

fulminant colitis

uncommon, life-threatening
entire colon - pain, diarrhea, dehydration/shock, SIRS. Deep colonic injury

22

most sensitive test for free air (as in toxic megacolon with perforation)

CT

23

What imaging for detail of mucosa?

barium contrast. CT is poor at this

24

CD location

any part of GI tract mouth to anus.

small bowel & proximal colon most common

25

CD age

peak at 20-29

26

aphthous ulcers association?

CD

27

rectal sparing?

CD

28

skip lesions

CD

29

deep ulcerations

CD

30

stricture formation

CD

31

fistulas

CD

32

CD:
small intestine alone %
small intestine & colon %
colon alone %

small intestine alone 30%
small intestine & colon 40%
colon alone 30%

33

noncaseating granuloma

CD

34

cobblestone mucosa

CD

35

inflammatory cells in CD

neutrophils, lymphs, plasma cells, eosinophils, macrophages w/granulomas (35%)

36

extra-intestinal manifestations of IBD (9)

enterocutaneous fistula
apthoid ulcer
erythema nodosum
pyoderma gangrenosum
scleritis, episcleritis, uveitis
gallstones
uric acid & oxalate stones
hypercoagulable state
peripheral neuropaty

37

IBD risk factors for colorectal CA (6)

extensive IBD
long term IBD
young age of onset IBD
backwash ileitis (UC)
family history of colorectal ca
hx of sclerosing cholangitis

38

etiology of CD & UC

CD - disordered response to intestinal bacteria
UC - autoimmune

39

creeping fat, bowel wall thickening

CD

40

lead pipe appearance on imaging

UC