Path TarC: CNS and Neuro Flashcards Preview

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Flashcards in Path TarC: CNS and Neuro Deck (13):

What viruses can cause cerebellar hypoplasia?

COWS - BVDV before 180d pregnancy (after this calf mounts immune response)
SHEEP - BTV (blue tongue virus) BDV (border dz virus) and Cache Valley virus in north America


What lesions does EHV1 cause? Clinical signs?

- random foci of haemorrhage, multiple segments of cord, predominantly grey matter
> ataxia, paralysis, recumbency


Path of EHV1?

- vasculitis consequences most noticeable in small aa./arterioles of SC
- multifocal tissue hypoxia and ischaemia
- neuronal axons respond in limited ways
- swell forming SPHEROIDS


how can EHV1 be dx clinically?

- PCR detection of virus in blood sample/CSF


Advice to owner if EHV1 suspected/dx?

- alert other woners on the yard
- don't transport/shows etc.


What pathogen causes FIP?

- FCoV mutated
- widespread in cats, usually only causes mild enteritis/subclinical disease until mutation occours


Pathogenesis of FIP?

> virus -> immune mediated dz
- immune complexes (vius Ab complexes) trapped in small vessels -> vasculitis -> effusive WET form (=EHV1 pathogenesis)
- continuous cell mediated immune response against infected macrophages causig granuloma in infected organs (DRY form)


Describe lesions found with supparaive bacterial meningitis

- pale yellow-cream exudate covering surface of brain within the meninges
- multifocal areas of haemorrhage


What bacteria can cause meningitis in piglets? What else can this pathogen cause?

> strep suis (ZOONOTIC)
- no uncommon cause of acute and frequent fatal meningitis in suckling and weanling pigs
- can also cause polyserositis (peritonitis, polyarthritis, pleuritis)


Clinical signs of rabies or rabies like virus (LYSSAVIRUS) in a cow?

- excessive salivation
- behavioural change
- muzzle tremors
- abnormal posture
- tenesmus
- opisthtonus
- seziures
- widespread paralysis and death


How deos abies/lylssavirus reach the brain?

retrograde axonal transport - replicates in neurons and glial cells once it has reached the brain


What histopathological findings are characteristic of lyssavirus infection?

- eosinophilic intracytolplasmic inclusion bodies


How can rabies be confirmed in the lab?

- no of techniques, based on fresh impession smears of the brain
> immunofluorescence and IHC most common
> viral isolation and PCR