Flashcards in Path TarC: CNS and Neuro Deck (13):
What viruses can cause cerebellar hypoplasia?
COWS - BVDV before 180d pregnancy (after this calf mounts immune response)
SHEEP - BTV (blue tongue virus) BDV (border dz virus) and Cache Valley virus in north America
What lesions does EHV1 cause? Clinical signs?
- random foci of haemorrhage, multiple segments of cord, predominantly grey matter
> ataxia, paralysis, recumbency
Path of EHV1?
- vasculitis consequences most noticeable in small aa./arterioles of SC
- multifocal tissue hypoxia and ischaemia
- neuronal axons respond in limited ways
- swell forming SPHEROIDS
how can EHV1 be dx clinically?
- PCR detection of virus in blood sample/CSF
Advice to owner if EHV1 suspected/dx?
- alert other woners on the yard
- don't transport/shows etc.
What pathogen causes FIP?
- FCoV mutated
- widespread in cats, usually only causes mild enteritis/subclinical disease until mutation occours
Pathogenesis of FIP?
> virus -> immune mediated dz
- immune complexes (vius Ab complexes) trapped in small vessels -> vasculitis -> effusive WET form (=EHV1 pathogenesis)
- continuous cell mediated immune response against infected macrophages causig granuloma in infected organs (DRY form)
Describe lesions found with supparaive bacterial meningitis
- pale yellow-cream exudate covering surface of brain within the meninges
- multifocal areas of haemorrhage
What bacteria can cause meningitis in piglets? What else can this pathogen cause?
> strep suis (ZOONOTIC)
- no uncommon cause of acute and frequent fatal meningitis in suckling and weanling pigs
- can also cause polyserositis (peritonitis, polyarthritis, pleuritis)
Clinical signs of rabies or rabies like virus (LYSSAVIRUS) in a cow?
- excessive salivation
- behavioural change
- muzzle tremors
- abnormal posture
- widespread paralysis and death
How deos abies/lylssavirus reach the brain?
retrograde axonal transport - replicates in neurons and glial cells once it has reached the brain
What histopathological findings are characteristic of lyssavirus infection?
- eosinophilic intracytolplasmic inclusion bodies