Patho Of MS Flashcards
Immune-mediated inflammatory disease of the CNS
Multiple Sclerosis
Activate peripheral t-cells breach____ and release chemicals to rally
Blood brain barrier
Immune system forces
MS ____x higher for person with affected relative
F:M ratio
10-50 x
3 women-1 men
Approximately 55-75% of pts have _____ at some point duringg course of disease
Spinal cord lesion
Optic nerve involvement and myelopathy
Neuromyelitis optica
Different MS classifications
Relapsing remitting MS
Secondary progressive MS
Primary progressive MS
Malignant MS
Accute attacks with full recovery
How many ppl Dx with this form initially?
Relapsing remitting MS (RRMS)
85%
Starts with RRMS followed by progression at variable rate with relapses and plateus
Secondary Progressive MS (SPMS)
50% of ppl with RRMS get it
Progression of disability from on w/ or w/o plateau, remission, improvement
Who has worst prognosis
Primary progressive MS (PPMS)
Progression from onset but clear acute relapses
Progressive Relapsing MS (PRMS)
Rare and results in death
Malignant MS
Symptoms lasting for more than 1-2 days
Relapse
What causes the axonal damage in MS
Inflammation
Dx of MS is based on
Med history
Signs + Symptoms
Lesions of MS are ____ and involve
Deep in brain and involve white matter (plaque)
MS lesions grouped into
4 patterns
Quantifies disability in 8 Functional Systems
Expanded Disability Status Scale (EDSS)
EDDS of 1-4.5 refer to MS that is ___
5-9.5 is
Fully ambulatory
Impaired ambulation
Symptoms of MS
Fatigue Pain Impaired ambulation bowel/bladder Motor impairments (just a summarization)
Factors of favorable prognosis
Female <35 y/o Monoregional Sensory vs motor Recovery after exacerbation
Less favorable Prognosis of MS
Male >35 Cerebellar symptoms Decreased recovery African-American
2 aspects of medication Tx for MS
Immunomodulatory Therapy
Symptom Modifying
Disuse process that occurs slowly and unnoticed..
Decreased by exercise
Creeping diability
Pts with MS have __ less aerobic capacity
30%
