Pathology

Question 1

Pneumonia pathology (4 marks)

Answer 1

During pulmonary infection, acute inflammation (1 mark) results in the migration of neutrophils out
of capillaries and into airspaces (alveoli) (1 mark), these cells phagocytose and release
antimicrobial enzymes and inhibitors (1 mark) → more inflammation and oedema (1 mark

Question 2

Tendinopathy pathology

Answer 2

Altered tendon cell population
Increased number of tenocytes, increased metabolism
Increased apoptosis
Immunoreactive cells

Disorganisation of collagen
Reduced type 1
Increased type 3
Higher concentration of Immature collagen bundles

Ground substance changes
Chemical alterations in a higher water content

Neovascularisation
Influx of blood vessels and nerves