Pathology 2 Final Flashcards
(46 cards)
What disease is associated with a mutation in type 1 collagen?
Osteogenesis imperfecta
Give a potential diagnosis based on this xray and histological slide:
xray: multilocular radiolucency crossing midline of anterior mandible, root resorption (third molars not in yet so its a kid)
histology: multinucleated giant cells (Aka chocolate chip cookies)
Central giant cell granuloma
All of the following describe mccune Albright syndrome except:
a- cafe au lait pigmentation
b- multiple endocrine lesions
c- polyostotic disease of fibrous dysplasia
d- hypo function of cells involved in the tissues
d- hypo function of cells involved in the tissue
What is a potential diagnosis for a patient with intestinal polyps?
gardner syndrome
An immunohistochemistry test for multiple myeloma would likely present what?
monoclonal light chain
What disease is associated with amyloid deposits
multiple myeloma
What is the gene mutation for cherubim?
SH3P2
What would you expect to see under an electron microscope for langerhans cell histocytosis?
birbeck granules
What disease is commonly associated with supernumerary teeth?
Gardners syndrome
Differential diagnosis for xray:
- posterior mandible
- large well circumscribed radiolucency
- involving the roots
- tooth “Floating in air”
Langerhans cell histiocytosis
Patient is 70 years old and present with this radiograph (punched out radiolucencies all over skull). What is your diagnosis?
multiple myeloma
Upon a biopsy of a lesion, what are you expecting to find for the histology of a focal osteoporotic defect?
hematopoietic bone marrow defect
Patient presents with this lesion that hasn’t expanded in 10 years. Pulp testing reports VITAL. What is your diagnosis?
xray:
- associated with molar-premolars
- radiopacity
idiopathic ostosclerosis
- increased radiopacity, non-expansile, mandibular molar-premolar area, vital teeth
List 3 differential diagnosis for this xray:
- OKC
- Conventional amelobastoma
- Central giant cell granuloma
Radiograph of a unilocular radiolucency, what can this NOT be?
botryoid odontogenic cyst (mulilocular)
radiograph of odontoma. what cyst is most commonly associated?
Calcifying odontogenic cyst (gorlin cyst)
Histology presents a corrugated surface, prominent, palisaded, hyperchomatic basal layer. What is most likely the radiographic presentation?
multilocular radiolucency (OKC)
What is the reason for the recurrence of OKC?
satelite cysts (daughter cysts)
A 50 year old male comes in with this radiograph (huge multilocular mass in posterior mandible)
What is NOT in your differential diagnosis?
Ameloblastic fibroma because this is a “kiddie” tumor
Which of the following will you not see with nevoid basal cell carcinoma syndrome? (gorlin syndrome)
multiple ameloblastomas
you will see: bifid ribs, multiple OKCs, nervous system neoplasms (medulloblastoma)
Histology shows ghost cells, what is this?
calcifying odontogenic cyst
Patient presents with vital teeth and a radiolucency that scallops the border of the roots. On biopsy the surgeon reports and empty cavity. The patient reports having sports injury in the area.
traumatic bone cyst
What presents with normal hematopoietic bone marrow histology?
osteoprotic bone defect
Histology shows REVERSE POLARITY of basal cell nuclei, NUCLEAR HYPERCHROMATISM, NUCLEAR PALISADING, and SUBNUCLEAR VACUOLATION. What is it?
unicystic ameloblastoma
