Pathology of Bone Tumors Flashcards Preview

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Flashcards in Pathology of Bone Tumors Deck (28)
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1

Giant Cell Tumors are found where?

EPIPHYSIS

2

What two bone tumors are normally found in the METAPHYSIS?

Chondrosarcoma
Osteosarcoma

3

EWING SARCOMA are found where?

DIAPHYSIS (ALWAYS)

4

rare benign tumor of mature bone
usually asymptomatic

Osteoma

5

Age: 40-50 yo

Site: cortical bones of skull and face

X-ray: well-delimited nodule

Osteoma

Prognosis:
good (simple excision)
slow-growing
not invasive
no malignant transformation

6

Bone tumor that presents with PAINFUL LESIONS

central area of tumor (nidus)

Osteoid osteoma & Osteoblastoma

- osteoblastoma = “giant osteoid osteoma

7

pain is relieved by ______ in osteoid osteoma where it is not in osteoblastoma

aspirin

8

20 year old presents with pain around the knee. What benign tumor could it be?

Osteoid Osteoma

9

Age:teens- twenties

Site: vertebral column, other

Size: > 2 cm

X-ray: radiolucent nidus, less (or no) sclerotic rim

Prognosis: good, if totally excised

Osteoblastoma

10

most common 1° malignant tumor of bone (20% of 1° bone malignancies); M:F = 1.6:1

Osteosarcoma

11

If you dont see ____ you can not call it an osteosarcoma.

Osteoid

12

malignant mesenchymal tumor; neoplastic cells produce osteoid (unmineralized bone matrix); sometimes makes cartilage

Osteosarcoma

usually arises in metaphysis of long bones of extremities

Paget disease, chronic osteomyelitis, prior irradiation, bone infarcts, fibrous dysplasia

13

aggressive !!!
20% with pulmonary mets at time of diagnosis

Osteosarcoma

grows so rapidly that it destroys other bone ( PAINFUL)

14

How do you diagnose osteosarcoma?

Need to see Osteoid

15

Elevation of periosteum
to produce an angle between
surface of involved bone

Osteosarcoma – Codman Triangle

16

Mushroom with a stalk

Age (young)
Site: Metaphysis
Prognosis: Good if solitary but if multiple you have increased risk of developing chondroSARCOMA

Osteochondroma (Cartialge forming)

17

Bening tumors of hyaline cartilage; well circomsribed
- Most common in hands an feet

In medullary -->_______

Chondroma

Enchondromas

18

Most common intra osseous cartilage tumor

Found in metaphyses of tubular bones PARTICULARLY HANDS AND FEET

- young patient

Chondroma


Ollier Disease --> Multiple chondromas

19

Malignant version of chondroma is chondrosarcoma which is normally located where?

Pelvis bones axial skeleton
-
Prognosis --> depends on grade (size are important)

20

_______ is a tumor of the AXIAL skeleton

Chondrosarcoma

21

1. Small round blue tumors

2. Primative neural tumors derived from a precursor multipotent mesenchymal stem cell ( HOMER WRITE ROSETTES)

1. Ewing Sarcoma

2. Primitive Neuroectodermal Tumor (PNET) ( MORE MATURE then above)

22

Ewing Sarcoma (EWS)
or
Primitive NeuroEctodermal Tumor (PNET

undifferentiated

EWS

23

Ewing Sarcoma (EWS)
or
Primitive NeuroEctodermal Tumor (PNET

neural differentiation (--> Homer Wright rosettes)


PNET

24

found in 30 - 50% of children 4-8 yo
probably developmental defect rather than neoplasm


Fibrous Cortical Defect

most arise in metaphysis of distal femur & proximal tibia (most common = knee)

Resolve spontaneously

25

Scalloped Margin

Fibrous Cortical Defect

26

curvilinear spicules of immature woven bone (Chinese characters) surrounded by fibroblastic proliferation

Fibrous Dysplasia

Prognosis: good

27

contains numerous osteoclast-like multinucleated giant cells mixed with mononuclear stromal cells

Arise in the _____

Giant Cell Tumor of Bone

osteoclastoma

Epiphyses of long bones
- Pain in the knee is an example

28

_______tumors to bone
are at least 20 X more common than primary bone tumors.

Metastatic

Most metastatic lesions are osteolytic;