Pathology of gastric diseases Flashcards Preview

GI > Pathology of gastric diseases > Flashcards

Flashcards in Pathology of gastric diseases Deck (26):
1

Which portion of the gastric mucosa varies? Which part remains the same?

Foveolar compartment=same
Glandular compartment=varies

2

What does the oxyntic mucosa produce?

acid and pepin

3

What are three congential lesions of the stomach?

1. pancreatic heterotopia (pancreas doesn't separate from teh stomach)
2. hernias (increased risk of GERD)
3. congenital hypertrophic pyloric stenosis (early projectile vomiting)

4

What are risk factors for acute gastritis?

NSAIDs, alcohol
bile reflux
smoking
severe hypotension or stress

5

What would you see in intestinal metaplasia?

Lots of mucin, producing cells

6

Which layer of the stomach contains major vessels?

The submucosa. If ulcer erode to this depth, can have hemorrhage

7

What is autoimmune gastritis?

Antibodies against parietal cells. Will see gastric atrophy and intestinal metaplasia. Also, endocrine cell hyperplasia

8

What are you at risk of developing if you have autoimmune gastritis?

Neuroendocrine tumors (i.e. carcinoids)
Adenocarcinoma

9

How do you stain for gastric carcinoids?

chromogranin immunostaining

10

Menetrier disease

Hypertrophic Gastropathy=foveolar hyperplasia

11

What are four types of gastric polyps?

1. hyperplastic
2. Gastric fundic
3. Peutz-Jeghers
4. Adenomatous

12

Which type of polyp is malignant?

adenomatous polyp

13

What is gastric fundic polyp assoc'd with?

Familial adenomatous polyposis and PPIs

14

What does Peutz-Jeghers polyp look like?

Arborizing smooth muscle layer

15

What are four types of gastric malignancies?

Adenocarcinoma (90%)
Lymphoma
Neuroendocrine (carcinoid)
GI stromal tumor

16

What are the two types of gastric adenocarcinoma?

Intestinal:
-Dysplasia before
-arises in glands
-more common in men

Diffuse:
-Linitis plastica
-No dysplasia before
-Arises in individual cells, no discrete mass

17

What is the most important prognostic variable in gastric adenocarcinoma?

depth of invasion

18

How do you stage adenocarcinomas?

TNM

19

What is a common metastasis site for adenocarinoma of the stomach/

Virchow's node

20

Krukenberg tumor:

Bilateral ovarian metastases

21

How does H pylori cause MALT lymphoma?

H pylori stimulates T cells
T cells activate B cells-->malignancy

22

How do you treat MALT lymphoma?

Antibiotics alone. But if cells have acquired t(11,18) then need to treat like a lymphoma

23

Where do gastric carcinoids arise from?

ECL cells

24

What kinds of cells are GI stromal tumors linked to?

Interstitial cells of cajal?

25

What mutations would you see in GI stromal tumors?

C-kit or PDGFR-alpha tyrosine kinases have activating mutations

26

How do you treat GI stromal tumors?

imatinib