Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.

Risks and benefits of inflammatory bowel disease therapy Flashcards Preview

GI > Risks and benefits of inflammatory bowel disease therapy > Flashcards

Flashcards in Risks and benefits of inflammatory bowel disease therapy Deck (6)
Loading flashcards...
1

What are the 5 options we have for treating IBD?

1. 5-ASAs
2. Antibiotics
3. Corticosteroids
4. Immunomodulators
5. Biologics (antibodies)

2

What are the primary cells modulating crohns? how about UC?

1. Crohn's=CD4+ T cell Th1
2. UC=CD4+ T cell Th2

3

What are the three ways in which drugs can modulate the immune system?

Corticosteroids block the trafficking of neutrophils to the gut mucosa

Methotrexate/6MP block the proliferation of T cells through inhibiting purine synthesis. Cyclosporine and tacrolimus inhibit IL-2 signals

ADAs and biologics work by inhibiting T cell regulation through cytokines

4

Which type of IBD is mesalamine (5-ASA) effective for?

ulcerative colitis, NOT crohn's

5

What is the most effective therapy for IBD?

Combo Azathioprine plus infliximab

6

Why might a patient not want to take a combo therapy?

They hear about a serious adverse event, but the risks are small. Risks of everyday life are higher than risks of taking their medications.

Decks in GI Class (27):

Brainscape is a web and mobile study platform that helps you learn things faster. Our mission is to create a smarter world by simplifying and accelerating the learning process. © 2021 Bold Learning Solutions. Terms and Conditions