Risks and benefits of inflammatory bowel disease therapy Flashcards Preview

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Flashcards in Risks and benefits of inflammatory bowel disease therapy Deck (6)
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1

What are the 5 options we have for treating IBD?

1. 5-ASAs
2. Antibiotics
3. Corticosteroids
4. Immunomodulators
5. Biologics (antibodies)

2

What are the primary cells modulating crohns? how about UC?

1. Crohn's=CD4+ T cell Th1
2. UC=CD4+ T cell Th2

3

What are the three ways in which drugs can modulate the immune system?

Corticosteroids block the trafficking of neutrophils to the gut mucosa

Methotrexate/6MP block the proliferation of T cells through inhibiting purine synthesis. Cyclosporine and tacrolimus inhibit IL-2 signals

ADAs and biologics work by inhibiting T cell regulation through cytokines

4

Which type of IBD is mesalamine (5-ASA) effective for?

ulcerative colitis, NOT crohn's

5

What is the most effective therapy for IBD?

Combo Azathioprine plus infliximab

6

Why might a patient not want to take a combo therapy?

They hear about a serious adverse event, but the risks are small. Risks of everyday life are higher than risks of taking their medications.