Flashcards in Risks and benefits of inflammatory bowel disease therapy Deck (6)
What are the 5 options we have for treating IBD?
5. Biologics (antibodies)
What are the primary cells modulating crohns? how about UC?
1. Crohn's=CD4+ T cell Th1
2. UC=CD4+ T cell Th2
What are the three ways in which drugs can modulate the immune system?
Corticosteroids block the trafficking of neutrophils to the gut mucosa
Methotrexate/6MP block the proliferation of T cells through inhibiting purine synthesis. Cyclosporine and tacrolimus inhibit IL-2 signals
ADAs and biologics work by inhibiting T cell regulation through cytokines
Which type of IBD is mesalamine (5-ASA) effective for?
ulcerative colitis, NOT crohn's
What is the most effective therapy for IBD?
Combo Azathioprine plus infliximab