Pathology of the mouth/esophagus Flashcards Preview

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Flashcards in Pathology of the mouth/esophagus Deck (33):
1

What are the 3 Ms of a pathological HSV specimen/

1. Multinucleation
2. Margination of the nucleus
3. Molding of the nucleus

2

What cells does HSV infect?

epithelial cells

3

What are the features of cytomegalovirus?

Owl-eye appearance

4

What types of cells does CMV infect?

endothelial and mesenchymal cells

5

What does mucormycosis look like?

ONLY broad bulbous hyphal forms that are at 90 degree angles

6

Pyogenic granuloma

Benign lobular capillary hemangioma

7

Aphthous ulcer

self-resolution. Canker sore

8

Leukoplakia

A white, hard, firm plaque. We worry that this will turn malignant.

9

Hairy leukoplakia: benign or malignant? What is it associated with?

Benign. Seen in HIV pts assoc'd with EBV infection.

10

What will you see on a hairy leukoplakia specimen?

hyperkeratosis, balloon cells, and acanthosis

11

Erythroplakia

Pre-malignant

12

What is squamous cell carcinoma assoc'd with?

smoking, alcohol, and HPV

13

In which salivary glands are neoplasms most likely to be malignant?

sublingual

14

What are two types of benign salivary gland tumors?

pleomorphic adenoma
warthin tumor

15

What are three types of malignant salivary gland tumors?

mucoepidermoid carcinoma
Acinic cell carcinoma
Adenoid cystic carcinoma

16

What types of cells do you see in a pleomorphic adenoma? Where are they most commonly found?

epitheial and myoepithelial. Found in the parotid gland

17

What are you worried about with a pleomorphic adenoma of the salivary gland?

Malignant transformation has a poor prognosis

18

Where would you find a warthin tumor?

parotid

19

What are the two components of a warthin tumor?

epithelial and lymphoid

20

What is the most common malignant tumor of the salivary gland?

Mucoepidermoid carcinoma

21

What are the two types of cells in a mucoepidermoid malignant tumor?

mucus secreting and squamous

22

What is a typical finding in a adenoid cystic carcinoma?

Perineural invasions

23

Which of these salivary neoplasms has the best survival?

Mucoepidermoid

24

In what conditions would you see an esophageal web?

Plummer vinson syndrome. Usually in women over 40

25

What are the components of plummer vinson syndrome?

1. Web
2. Anemia
3. Gossitis
4. Cheilosis
5. Upper esophagus carcinoma

26

What is a mallory-Weiss tear? How would it present?

Laceration at the GEJ. Will see forceful vomiting

27

What is Boerhaave syndrome?

Esophageal rupture. Catastrophic

28

In which patients would you see esophageal varices?

cirrhotic pts (90%!)

29

What are the two types of esophageal carcinoma?

Squamous cell carcinoma and adenocarcinoma

30

What kind of carcinoma does Barrett's esophagus give rise to?

adenocarcinoma

31

What are the criteria for Barrett's esophagus?

1. Endoscopic evidence of columnar epithelium
2. Intestinal metaplasia (goblet cells)
-->The presence of goblet cells defines barrett esophagus

32

How do you treat a platient with BE?

Routine surveillance and biopsy.

33

What is the standard of care Tx for esophageal adenocarcinoma?

Esophagectomy. High morbidity and mortality