patterning

Question 1

roof plate

Answer 1

dorsalising
interneurons
bmp wnt

Question 2

floor plate

Answer 2

ventralising
motor neurons
shh

Question 3

notochord removal effect (patterning)

Answer 3

no motor neurons
notochord secretes SHH -> ESSENTIAL for motor neurons)

Question 4

ectopic notochord on neural tube

Answer 4

induces motor neurons

Question 5

ap patterning

Answer 5

elongation of neural tube
develop brain bulges and SC

Question 6

cerberus
ap patterning

Answer 6

antagonise nodal WNT signalling
prevents BMP signalling

Question 7

dickopf
ap patterning

Answer 7

competes WNT from receptors (prevents wnt signalling)

Question 8

otx2

Answer 8

requires for DKK
activates FGF2

Question 9

wnt (in midbrain hindbrain signaling)

Answer 9

activates FGF

Question 10

fgf (in midbrain hindbrain signaling)

Answer 10

activates otx2

Question 11

secondary organisers

Answer 11

stretch at both sides to produce three ventricle phase

Question 12

ectopic fgf8

Answer 12

results in ectopic midbrain formation

Question 13

homeobox gene expression

Answer 13

defines AP patterning

Question 14

hox gene

Answer 14

clusters aligned on chromosome in order of expression
targets of WNT, Shh, FGF, RA