Pediatric Food Allergies Flashcards Preview

Block 3 Week 8 > Pediatric Food Allergies > Flashcards

Flashcards in Pediatric Food Allergies Deck (49)
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1

What are the 2 ways you can classify adverse food reactions?

1)immunologically mediated
2)food interolerance

2

What are the 2 kinds of immunologically mediated adverse food reactions?

mediated by IgE
non IgE mediated (take hours to evolve)

3

What is food intolerance?

Adverse physiologic response to a food or food additive not immunologically mediated

4

Immune reponses to food are considered food allergies while non immune adverse reaction are considered to be a problem in one of four different categories which are?

metabolic
pharmacologic
toxic
other

5

What are the five metabolic disorders that can cause adverse reactions to food?

lactase deficiency
fructose intolerance
galactosemia
pancreatic insufficiency
gallbladder/ liver disease

6

What are the four pharmacological disorders that can cause adverse reactions to food?

histamine
tyramine
caffeine
theobromine

7

What are the three toxic disorders that can cause adverse reactions to food?

food poisioning
scombroid fish poisioning
ciguaterra fish poisoning

8

What are considered to be part of the 'other' category of non immune related adverse food reactions?

panic, anxiety
hiatal hernia
reflux

9

What are food allergens?

water soluble glycoproteins that are heat and proteolysis resistant that get absorbed across mucosal surfaces

10

What are these:
peanut Ara h1, Ara h2, and Ara h3
chicken egg white Gal d1, Gal d2, and Gal d3;
soybean-Gly m1
fish-Gad c1
shrimp-Pen a1.

purified food allergens

11

How many people think they have food allergies?
actual?

30% believe 1 family member has it
6% in infants and 3.7% of adults

12

What are the most common food allergies in children?

cow milk, 2.5%
eggs, 1.3%
peanuts, 0.8%
wheat, 0.4%
soy, 0.4%

13

Is a food allergy a disease?
When is it most prevalent?

yes
in children, after age 15 it drops (allergies disappear with age and dont occur as often in later years)

14

What does IgE mediated adverse food reactions cause?

anaphylaxis, food associated excercis induced anaphylaxi, uticaria (hives) /angioedema (swelling), immediate GI problem, pollen-food allergy syndrome, bronchospasm

15

What will mixed IgE mediated and non mediated adverse food reactions cause?

atopic dermatitis (exzema), asthma, eosinophilic esophagitis/gastroenteritis

16

What will non-IgE mediated adverse food reactions cause?

dermatitis herpetiformis, celiac disease; enteropathy, food-induced enterocolitis syndrome, allergic proctocolitis, Heiner's syndrome

17

Is celiacs disease IgE mediated?

NO

18

What is the most common mechanism of food hypersensitivity?

IgE

19

Where do we find mast cells and basophils and why is this important?

in skin, Gi tract, and respiratory tract
cuz when IgE is activated by specific antigen it will bind to these mast and basophils and cause the IgE to dimerize and cause cross-linking which will release histamine, prostaglandins, leukotrienes, chemotactic factors, and cytokines

20

What does IgE due to you vascular system and smooth muscle?

vasodilation, smooth muscle contraction and mucus secretion

21

Is the IgE reaction fast or slow?

Super fast

22

Is IgE specific to an antigen?

yes

23

What is anaphylaxis?

worse case scenario and caused within hour of food ingestion and is IgE mediated

24

What are these symptoms of:
Urticaria, angioedema, difficulty breathing, wheezing, hypotension, oropharyngeal pruritus, angioedema, stridor, dysphonia, cough, dyspnea, nausea, vomiting, diarrhea, flushing
“Sense of impending doom”

Food anaphylaxis

25

How do you die from anaphylaxis?

Fatalities result from severe laryngeal edema, irreversible bronchospasm, refractory hypotension, or a combination.
(HAPPENS REALLY FAST SO BE AWARE)

26

What is pollen-food allergy syndrome?

patients eat food and get itching/tingling/ on tongue, palate, throat not due to food, but due to a pollen allergy (lots of food have the same protein of pollen in their skin)

27

Bananas, pumpkins, and melons have a specific protein in them as (blank) pollen which will induce a allergic reaction.

ragweed

28

What is this:
Caused by cross-reactivity between certain pollen and food allergens.

Pollen-food allergy syndrome (Oral allergy syndrome)

29

What are the four tests needed to test food allergies?

Skin tests
RAST tests
Patch tests
Food Challenges

30

What is the allergy prick test (skin test)?

Used for immediate hypersensitivity reactions (IgE)
has high false positive rates
uses fruits and vegetables
test is blocked with antihistamines