Perinatal Adaption at Birth Flashcards

1
Q

What are the main roles of the placenta?

A
Foetal homeostasis
Gas exchange
Nutrient-waste transport
Acid base balance
Hormone production
IgG transport
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2
Q

How much of the cardiac output goes to the lungs in-utero?

A

7%

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3
Q

What are the three main shunts in a foetal heart?

A

Ductus arteriosus
Ductus Venosus
Foramen Ovale

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4
Q

In a developing foetus, the lungs have a ____ resistance while the placenta/systemic resistance is ____

A

High resistance in lungs

Low resistance systemically

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5
Q

What vein is responsible for keeping the ductus venosus open?

A

Umbilical vein

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6
Q

At what gestational age does the foetus begin developing alveoli

A

36 weeks

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7
Q

Where does brown fat accumulate?

A

Between scapula

Around internal organs

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8
Q

What adaptions does the foetus go through in preparation for birth in 3rd trimester?

A

Surfactant production
Accumulation of glycogen
and brown fat
Swallowing of amniotic fluid

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9
Q

What hormones increase during the onset of labour?

A

Catecholamines and cortisol

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10
Q

What is a large benefit of vaginal delivery?

A

Squeezes the lungs to encourage fluid movement into interstitial lung tissue

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11
Q

What increases as the cord stops pulsating?

A

CO2

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12
Q

What happens to the pressure when a baby cries?

A

Huge increase in intrathoracic pressure pushing fluid out of lungs and into interstitial tissue

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13
Q

What changes occur to the circulation post-delivery?

A
Pulmonary vascular resistance decreases
Systemic resistance increases
O2 tension rises
Circulating prostaglandins decrease
Duct constricts
Foramen ovale closes
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14
Q

What % of foramen ovale do not close?

A

10%

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15
Q

What does the ductus arteriosus become normally?

A

Ligamentum arteriosus

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16
Q

What does the ductus venosus become?

A

Ligamentum teres

17
Q

What must you do to confirm a diagnosis of persistent pulmonary hypertension of new-born? (PPHN)

A

Pre and post ductal oxygen saturations

18
Q

List some management options of PPHN

A
Ventilation
Oxygen
Nitric oxide
Sedation
Inotropes
ECLS
19
Q

Why should you not increase systemic resistance in babies with PPHN

A

Makes it harder for blood to cross the ducts, forcing more blood into the lungs

20
Q

What is the main source of heat production in new-born?

A

They cannot shiver
Non-shivering thermogenesis through breakdown of brown adipose tissue
Peripheral vasoconstriction

21
Q

What can be causes of physiological jaundice in a new-borns

A

Breakdown of foetal haemoglobin
Rise in unconjugated bilirubin
Conjugating pathways not matured

22
Q

When is jaundice considered pathological?

A

Early or late

<3 days or >10 days