Flashcards in Pharm 1 - Exam 1 Deck (85):
What is an non-selective adrenergic agonist used in the treatment of asthma?
What form of administration is ineffective for Epinephrine?
Name the long-acting beta 2 adrenergic agonist for asthma.
Which asthma drug must be used in conjunction with other therapies?
What inhibits Salmeterol?
What is the class of drugs Ipratropium/Atrovent is in?
Which asthma medication has the narrowest TI and in which class is it?
*looks like caffiene
If you want to give an inhaled corticosteroid to an asthma patient, what med would you use?
If you have a patient with COPD or worsening asthma, what corticosteroid would you give?
Name a leukotriene inhibitor used in the treatment of chronic asthma. What enzymes does this drug inhibit?
What other class of drugs is often added to antitussives used in COPD?
Name two antitussives and their classes given for COPD.
Codeine (narcotic analgesic/cough suppressant)
Dextromethorphan/DM (synthetic derivative of morphine/cough suppressant)
What is the MOA and #1 side effect for Diphenhydramine/Benadryl?
Histamine 1 receptor site blockage
Which drug is a non-sedating antihistamine used for allergic rhinitis? Why is it non-sedating?
Don't cross BBB
T/F. Both Dephenhydramine and Loratadine block the production of histamine.
False. The receptor is just blocked.
Which drug would you choose if you wanted a nasal corticosteroid for treating nasal rhinitis?
What is the most addictive OTC drug and its class? Hint: it's used to treat allergic rhinitis.
This drug has the rebound effects of rhinitis medicosum
What is the most effective smoking cessation drug and its MOA?
partial agonist of alpha4/beta2 nicotinic acetylcholine receptor sites
What is the second most effective smoking cessation drug? What is it's MOA?
dopamine-NE reuptake inhibitor (depression med)
What drug is based on the Ayurvedic herb Khella?
What stage of HTN is a BP of 160-179/100?
What stage of HTN is a BP of 140-159/90s?
What Stage of HTN is a BP of >180/>110?
Stage 3/malignant HTN
Which HTN med is contraindicated in patients with low GFR and gout patients?
Is Hydrochlorthiazide/Hydrodiuril K+ sparing or wasting?
Which two drugs help the K+ wasting of Hydrochlorthiazide/Hydrodiuril?
Which class of drugs has the strongest diuretic effect?
Name a loop diuretic. Is it safe to use in patients with renal failure?
No, it's not effective for pts with renal failure but it is the drug of choice for those with low GFR or in hypertensive emergencies
What are the MC side effects of diuretics?
Which of the diuretics is most likely to cause hypercalcemia?
What is a common dose of K+ given to patients on K+ wasting diuretics?
10mE or 750mg KCl
Which diuretic is K+ sparing?
Which diuretic is a direct aldosterone antagonist?
Do not use this diuretic for pts taking K supplements, ACE inhibitors or ARBs OR those with renal insufficiency, uncontrolled DM or osteomyelitis.
This K+ sparing diuretic is a Na+ channel blocker
Where are the highest concentration of Beta 1 and Beta 2 receptors?
What is the antidote to b-blockers? MOA?
increase cAMP in myocardium, bypasses beta adrenergic 2nd messenger system
Which patients should not be given Propanolol/Inderal?
COPD/asthma (it is known to cause bronchospasm)
cardiac conduction abnormalities
What class of drugs may result in rebound tachycardia, HTN, stroke of MI if discontinued suddenly?
Name 3 Category X drugs
Lisinopril (ACE inhibitor)
Lorsartan (angiotensin II receptor blocker)
This drug is a cardiac specific beta 1 blocker
This class of drugs is known to cause weakness, fatigue, lethargy, depression, CNS disturbance, sexual dysfunction, bradycardia
What three conditions in addition to HTN would lead someone to use a beta blocker as a first line therapy?
MI soothed by beta blockers previously
Which of the alpha blockers blocks alpha 1 receptors?
What is the MOA of Rauwolfia Alkaloids/Reserpine?
Peripheral adrenergic blockade
Name the Ca Channel Blocker
What drug is most indicated for treating vasospastic angina in addition to HTN?
What is the risk of using Ca Channel Blockers with beta blockers?
What is the drug of choice in treating pts with HTN and DM? What is its class?
Lisinopril/Prinivil (ACE inhibitor)
Which drug inhibits the degradation of bradykinins, resulting in a dry irritating cough?
Someone comes in with angioedema. What drug might they be taking?
What class of drugs should Lisinopril never be mixed with?
K+ sparing diuretics. It has a potential for hyperkalemia on its own
What is the drug of choice in treating HTN with CHF of DM in conjunction with proteinuria? What is it's class?
What is the MOA for Losrtan/Cozaar (ARB)?
blocks the effects of angiotensin II, decreasing peripheral vasoconstriction.
This drug does not block the degredation of bradykinins and therefore produces less of a cough compared to ACE inhibitors
This drug reduces peripheral sympathetic nervous activity by stimulating the presynaptic alpha2 adrenergic receptors in the CNS.
What drug might you use when a pt's HTN does not respond to 2-3 meds concurrently?
In what class of drug is Methyldopa/Aldomet?
Centrally Acting Alpha Agonist
Name 2 direct vasodilators and their most notable side effects.
Minoxidil/Loniten (hirsuitism) AKA Rogaine
Hydrakazine/Apresoline (Drug-induced SLE)
What drug falls in the category of renin-blocker?
What is the MOA of IV Nitroglycerine and IV Sodium Nitroprusside and when might you use them?
NO = vasodilation of veins and arteries
A woman comes in with emergent pregnancy-induced HTN, what drug would be used?
What is the MOA for aspirin?
irreversibly inhibits COX 1 and 2 = decrease platelet agg.
Someone comes in with hyperventilation, tinnitis, dizziness, n/v. What is this constellation of symptoms called when associated with aspirin?
In what patients is aspirin indicated to reduce MI?
hx of infarction
This drug is an ADP receptor antagonist and is known to reduce the risk of thrombotic events
This anti-thrombotic drug is CI in pts with internal bleeding, intracranial hemorrhage, head trauma, or stroke w/i 30 days
What class of drug is Abciximab/Reopro?
Glycoprotein IIB/IIIA inhibitor
These three anti-coagulants inactivate factor X(Xa)
Enoxaparin/Lovenox (LMW Heparin)
What is the most unique side effect of Enoxaparin?
Heparin induced throbocytopenia (HIT) syndrome
discontinue if platelets drop below 100,000/mm3
Protamine sulfate antidotes what drugs?
Heparin, Enoxaparin/Lovenox (LMW Heparin)
This anticoagulant affects vitamin K dependent factors
This is the only drug that actually lyses clots via the activation of plasmin.
What drug should not be given to pts who have had reent head trauma, GI bleed, surgery or intracranial neoplasm within the last 30 days?
Which drugs should not be prescribed with Silendafil/Viagra?
Nitrates (nitroglycerin and Isosorbide Dinitrate/Isordil)
This is a long acting nitrate vasodilator
Beta blockers are mainly indicated in what conditions?
What is the antidote for Amlodopine/Norvasc (a Ca+ Channel Blocker)?
What drug might be used for pain relief in unstable angina?
morphine (opiate receptor agonist)
For what is Nalaxone/Narcan an antidote?
What is the acronym for unstable angina?
What is the antidote for Streptokinase?
What drug is particularly indicated for HTN and BPH?