Pharm - Exam 3 Flashcards Preview

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Flashcards in Pharm - Exam 3 Deck (50):
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1. What is phase III?

Efficacy compared to standard of care

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2. How do most chemo agents act?

Distrupt RNA

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3. Target therapies?

Induce apoptosis

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4. Differnce between Darbepoeitin & epoeitin?

Darbepoeitin has a longer 1/2 life than epoeitin.

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5. What is the MOA for vinca alkaloids?

Prevent microtubule formation

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6. When do taxanes work?

During S phase

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7. Which drug are we most worried about extravastation (most potent)?

Vinca alkaloids

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8. What are the monitoring paramaters for ESA’s?

Reticulocytes, serum iron, Hgb

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1. what do you need to do 1st for Dextran injections?

Needs a test dose for anaphylaxis

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10. Sickle cell crisis treatment of choice?

Hydration & pain management

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11. What does hydroxyurea do?

Increases Hgb F

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12. What are we measuring in animal tumor cell studies?

Efficacy

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13. What is the advantage of non cell cycle-specific drugs?

Can attack tumor cells in G0 as well as other CELL CYCLE phases

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14. What tumors are more sensitive to therapy?

Rapidly growing tumors because they have more cells that are actively dividing

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15. Who is at risk for pulmonary depression on Bleomycin?

pt w/ supplemental O2 & pulm dz

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16. what is used to prevent chronic, delayed cardiotoxicity

Cap anthracycline exposure

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17. What is the mechanism of TKI resistance?

Change in AA sequence, decreases binding affinity

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18. How long is the treatment for B12 deficiency?

Life long

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19. What is the best treatment for B12 deficiency?

Oral cobalamin

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20. What are the labs for Fe+deficiency anemia?

Low iron
High transferrin
Low transferring saturation
Increased TIBC
Microcytic

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21. What is an ESA side effect?

Thromboembolism

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22. What is a side effect of cytarabine?

Cerebellar toxicity

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23. Which is an alkylating agent?

Cyclophosphamide

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24. FA or B12 hgb response?

1-2 weeks

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25. What is the definition of remission?

Unable to detect presence of cancer

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26. Fe+ supplements?

All have different elemental iron but can all be used to treat iron deficiency

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27. ESA’s should?

Decrease the need for RBC transfusion

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28. What are Immunomodulators used to treat?

Multiple myeloma.

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29. Leukovorin MOI?

Increases activity of 5FU

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30. What is the MOA for Epipodophyllotoxins?

Inhibit DNA topoisomerase II

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31. What is Aspiraginase used for?

Cancer that requires extracellular asparagine for survival

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32. TKIs MOI

Prevent regular cell functions from occurring

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33. What do monoclonal antibodies target?

Specific pathways (EGR, HER2, CD)

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34. What is the advantage of having exposure to multiple drugs?

Wave—like -->to make sure most cells are destroyed in a constant fraction (log kill cell kinetics)

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35. What ist the Gompertzian model?

Larger tumors have less dividing cells, less susceptible to chemotherapies.

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36. What is the treatment regimen for AML?

7 + 3

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37. Breast cancer is?

Hormonally sensitive

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38. Breast cancer tx most important for choosing tx is?

Pre/postmenopausal status

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39. What is the goal of skin cancer tx (melanoma)?

Prolong survival

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40. What is the treatment for CML?

TKI---philadelphia chromosome

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41. What is the definition of adjuvant chemotherapy?

After surgery to get undetected cancer cells

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42. What is true of secondary malignancies?

Harder to tx than de novo cases.

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43. Anthracyclines also?

Produce free radicals.

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44. Chemotherapy?

Systemic therapy.

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45. What is cobalamin nasal spray used for?

Maintenance for a patient that has responded to oral/IM therapy

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46. Anemia presentation?

- Vertigo
- HA
- Dizziness
- Pallor
- Fatigue

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47. Anemia risk factor?

Pregnant or lactating woman

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48. What are three things that could reduce efficacy?

Pt specificcharacteristics (obesity, metabolism), mutations, decreased transport into cells, increased activity against drug  there were three correct options

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49. What can trigger a sickle cell crisis.

Dehydration

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50. What is a complication of sickle cell crisis?

CVA