1. Exams - Semester 3 > Pharm - Exam 1 > Flashcards

Pharm - Exam 1 Flashcards

(45 cards)

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1
Q
  1. What is the med that is indicated for the absence seizures only?
A

Ethosuximide

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2
Q
  1. Which drug has a side effect of weight loss?
A

Felbamate

Also : Ethosuximide, Topiramate, Zonisumide

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3
Q
  1. What drug does not cause diplopia?
A

Zonsiumide

Lacosamide, Lamotrigine, Phenytoin, Pregabalin, Tiagabine, Vigabatrin

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4
Q
  1. What are 2 drugs that are pan CYP inducers?
A

Phenobarb and CBZ

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5
Q
  1. What was false regarding gabapentin?
A

Not a pan inducer of hepatic enzymes

a. it is needed in high dose, is excreted unchanged, and has no known DIs

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6
Q
  1. How much active drug in phenytoin sodium?
A

0.92

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7
Q
  1. Calculate the loading dose
A

DL = (Vd)(Css)/(S)(F)

Vd = .65 x Wgt (Kg)

Css = 18!!!!

S (Sodium) Capsule & Injec = .92
S (Acid) Tablet & suspension = 1.0

F = 1

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8
Q
  1. Calculate the loading dose
A

(convert pounds to kg)

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9
Q
  1. What is the VPA dose range?
A

50-150

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10
Q
  1. What drug do you have to serum monitor?
A

Phenytoin (Also CBZ & VPA)

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11
Q
  1. What drug causes gingival hyperplasia?
A

Phenytoin

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12
Q
  1. What are the symptoms of acute intoxication of phenobarbitol?
A

Slurred speech,
Nystagmus,
Ataxia (unsteady gate)

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13
Q
  1. What is converted to phenobarb via hepatic oxidation?
A

Primidone

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14
Q
  1. What has to be tapered slowly to prevent rebound convulsions?
A

Phenobarb

Also Delirium

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15
Q
  1. Why do you have to start topirimate slowly?
A

Cognitive impairment

Used for migraines

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16
Q
  1. What’s not first line for early established stat epi?`
A

IV Valproate

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17
Q
  1. If you are on valproic acid and want to start lamotrigine why slowly?
A

SJS

Decrease Lamotragine by 50% if used in combo w/ VPA

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18
Q
  1. Typical first line for Parkinsons?
A

Rasagiline

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19
Q
  1. What is true about Diastat?
Study These Flashcards
A

all of the above

  • Used for breakthrough seizures,
  • When on established AED,
  • Gel formulation w/ rectal admin,
  • Can’t give more than 5x a month
20
Q
  1. Which of the following drugs has significant drug interaction?
Study These Flashcards
A

Valproic acid

NOT
Gabapentin
Levitiracetem
Pregabalin

21
Q
  1. Which drugs are used for general anesthesia in the treatment of stat epi?
Study These Flashcards
A

Midazolam & Propofol

22
Q
  1. What is true?
Study These Flashcards
A

All of the above

  • Lamotrigine level is inc during the placebo week,
  • CBZ interferes w estrogen and makes OCP ineffective,
  • Lamotrigine decreases the bioavailability of progesterone & makes OCP ineffective
23
Q
  1. What is true about Capylidene in the tx of Alzheimer’s?
Study These Flashcards
A

Not 1st line

  • It is a medical food
  • Watch for risk of ketoacidosis
  • Increases triglyceride levels
24
Q
  1. Pt with a h/o Alzheimer’s now has aggression w no other Sx?
Study These Flashcards
A

Anticonvulsants

25
25. Pt dx w new Alzheimer’s w h/o IBS, what should the initia tx be?
Donepezil
26
26. What drug causes memory loss?
NSAIDs
27
27. MOA of donepezil?
Ach inhibitor only
28
28. What cholinesterase inhibitor comes in a patch?
Rivastigmine
29
29. After 6 months what would the pts MMSE score would be if they started at 23?
24 (Inc 1-1.5)
30
30. Why do you use aspirin in the tx of AD?
Improve perfusion & helps w vascular dz
31
31. Alzheimer’s is now moderate, was on low dose donepezil, how should tx change?
Memantine Donepezil in high doses can be used for moderate to severe but the dose is 23 mg – question option suggested increases
32
32. MOA of memantine?
NMDA antagonist
33
33. Young Parkinson’s patient preventing w/ tremors, what should initial tx be?
Amantadine
34
34. What do you add to CD/LD to extend?
COMT inhibitor (Entecapone)
35
35. 70 yo w/ not otherwise specified Parkinson’s?
CD/LD
36
36. Delayed on/no-on?
Add apomorphine plus trimethomenzamine
37
37. Clinical predictor of disease in PD?
Decrease response to dopamine
38
38. Who will most benefit from starting CD/LD initially?
Older pt w/ cog and functional impairment
39
39. What is the rationale for using Selegeline in tx of PD?
Delay need for LD by 9 months
40
40. ADR of amantadine?
Tachyphylaxis in 1- 2 months
41
41. MOA of Rotigotine?
Dopamine antagonist
42
42. Which of the dopamine agonists need to be renally dose adjusted?
Pramipexole
43
43. What class has the ADR brown-orange urine?
COMT inhibitor
44
44. What are the side effects of Galantamine?
N/V/D
45
45. What drugs don’t you give to pregnant people?
all of the above Phenytoin, Valproic acid, Phenobarb
1. Exams - Semester 3
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