Pharm - Exam 1 Flashcards Preview

1. Exams - Semester 3 > Pharm - Exam 1 > Flashcards

Flashcards in Pharm - Exam 1 Deck (45):
1

1. What is the med that is indicated for the absence seizures only?

Ethosuximide

2

2. Which drug has a side effect of weight loss?

Felbamate

Also : Ethosuximide, Topiramate, Zonisumide

3

3. What drug does not cause diplopia?

Zonsiumide

(Lacosamide, Lamotrigine, Phenytoin, Pregabalin, Tiagabine, Vigabatrin)

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4. What are 2 drugs that are pan CYP inducers?

Phenobarb and CBZ

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5. What was false regarding gabapentin?

Not a pan inducer of hepatic enzymes

a. it is needed in high dose, is excreted unchanged, and has no known DIs

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6. How much active drug in phenytoin sodium?

0.92

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7. Calculate the loading dose

DL = (Vd)(Css)/(S)(F)

Vd = .65 x Wgt (Kg)

Css = 18!!!!

S (Sodium) Capsule & Injec = .92
S (Acid) Tablet & suspension = 1.0

F = 1

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8. Calculate the loading dose

(convert pounds to kg)

9

9. What is the VPA dose range?

50-150

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10. What drug do you have to serum monitor?

Phenytoin (Also CBZ & VPA)

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11. What drug causes gingival hyperplasia?

Phenytoin

12

12. What are the symptoms of acute intoxication of phenobarbitol?

Slurred speech,
Nystagmus,
Ataxia (unsteady gate)

13

13. What is converted to phenobarb via hepatic oxidation?

Primidone

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14. What has to be tapered slowly to prevent rebound convulsions?

Phenobarb

Also Delirium

15

15. Why do you have to start topirimate slowly?

Cognitive impairment

Used for migraines

16

16. What’s not first line for early established stat epi?`

IV Valproate

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17. If you are on valproic acid and want to start lamotrigine why slowly?

SJS

Decrease Lamotragine by 50% if used in combo w/ VPA

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18. Typical first line for Parkinsons?

Rasagiline

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19. What is true about Diastat?

all of the above

- Used for breakthrough seizures,
- When on established AED,
- Gel formulation w/ rectal admin,
- Can't give more than 5x a month

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20. Which of the following drugs has significant drug interaction?

Valproic acid

NOT
Gabapentin
Levitiracetem
Pregabalin

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21. Which drugs are used for general anesthesia in the treatment of stat epi?

Midazolam & Propofol

22

22. What is true?

All of the above

- Lamotrigine level is inc during the placebo week,
- CBZ interferes w estrogen and makes OCP ineffective,
- Lamotrigine decreases the bioavailability of progesterone & makes OCP ineffective

23

23. What is true about Capylidene in the tx of Alzheimer’s?

Not 1st line

- It is a medical food
- Watch for risk of ketoacidosis
- Increases triglyceride levels

24

24. Pt with a h/o Alzheimer’s now has aggression w no other Sx?

Anticonvulsants

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25. Pt dx w new Alzheimer’s w h/o IBS, what should the initia tx be?

Donepezil

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26. What drug causes memory loss?

NSAIDs

27

27. MOA of donepezil?

Ach inhibitor only

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28. What cholinesterase inhibitor comes in a patch?

Rivastigmine

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29. After 6 months what would the pts MMSE score would be if they started at 23?

24 (Inc 1-1.5)

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30. Why do you use aspirin in the tx of AD?

Improve perfusion & helps w vascular dz

31

31. Alzheimer’s is now moderate, was on low dose donepezil, how should tx change?

Memantine

Donepezil in high doses can be used for moderate to severe but the dose is 23 mg – question option suggested increases

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32. MOA of memantine?

NMDA antagonist

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33. Young Parkinson’s patient preventing w/ tremors, what should initial tx be?

Amantadine

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34. What do you add to CD/LD to extend?

COMT inhibitor (Entecapone)

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35. 70 yo w/ not otherwise specified Parkinson’s?

CD/LD

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36. Delayed on/no-on?

Add apomorphine plus trimethomenzamine

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37. Clinical predictor of disease in PD?

Decrease response to dopamine

38

38. Who will most benefit from starting CD/LD initially?

Older pt w/ cog and functional impairment

39

39. What is the rationale for using Selegeline in tx of PD?

Delay need for LD by 9 months

40

40. ADR of amantadine?

Tachyphylaxis in 1- 2 months

41

41. MOA of Rotigotine?

Dopamine antagonist

42

42. Which of the dopamine agonists need to be renally dose adjusted?

Pramipexole

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43. What class has the ADR brown-orange urine?

COMT inhibitor

44

44. What are the side effects of Galantamine?

N/V/D

45

45. What drugs don’t you give to pregnant people?

all of the above

Phenytoin, Valproic acid, Phenobarb