Pharmacodynamics Flashcards
(8 cards)
1
Q
*Pharmacodynamics
A
the study of drug effect, and mechanisms of action
What the drug does to the body
(drug action and mechanism)
2
Q
What are the targets of drug action?
A
- Simple chemical neutralisation
- Enzyme inhibitors – Antibiotics
- Receptor occupying drugs related to neurotransmitters
- Modulators of certain transport systems – e.g. Na+/K+ ATPase
- Ion channel interaction – e.g. local anaesthetics
3
Q
*receptor
A
Protein molecules that respond to endogenous chemicals (transmitters) in a lock and key fashion
4
Q
*affinity
A
Number of bonds and goodness of fit between drug and receptor
5
Q
*Specificity
A
Ability of drug to bind to one specific type of receptor
6
Q
*selectivity
A
No drug is truly specific, but many have relative selectivity on one type of receptor
7
Q
What are the 2 general functions of receptors?
A
Fast system of nerves
Slow endocrine system
8
Q
What are the different receptor types?
A
Ligand gated ion channels
G protein coupled receptors
kinase linked receptors
nuclear receptors
