Pharmacodynamics - Receptors Flashcards
(28 cards)
what is drug action
initial consequences of drug-target combination
what is the effect of the binding of an appropriate ligand to a receptor
regulatory signal sent to target cell
what type of responses can be seen from the binding of a ligand to a receptor
physiological or pharmacological
what is an example of an endogenous neurotransmitter
hormones
what type of ligand is a drug
exogenous
what are exogenous ligands
those that are introduced into the body
what is the weakest chemical force
Van der Waals
what is the most common bond with drugs/receptors that is irreversible
covalent bonds
what is the “hierarchy” of bond strength
covalent > ionic > hydrogen > Van der Waals
what type of receptor has unknown ligands
orphan receptors
what type of receptors are regulated by agonists
ionotropic receptors
what is an example of an ionotropic receptor
ligand gated ion channel
what type of receptor affects the metabolic process within the cell
metabotropic
what are the types of receptors?
- ligand-gated
- G protein coupled receptors
- Protein Tyrosine Kinase
- Intracellular Receptors
which receptor mediates the response of insulin and growth factors
Protein Tyrosine Kinase
what receptor is activated by hormone groups IN A CELL
intracellular receptors
what receptor only opens when the receptor is occupied by an agonist
ligand gated ion channel
what receptor has the quickest response time
ligand gated ion channel
what receptors are regulated by adenylyl cyclase, phospholipase C, and Ca+/K+ channels
G-Protein Coupled Receptors
what halts the activity of a GPCR
hydrolysis of the GTP to GDP
what type of response can a GPCR induce
stimulatory or inhibitory
what is the purpose of the G alpha-s protein
increase adenylyl cyclase
increase cAMP
what is the purpose of the G alpha-s protein
increase adenylyl cyclase
increase cAMP
what is the purpose of G alpha-i
decrease adenylyl cyclase
decrease cAMP
