Pharmacogenomics Flashcards
1
Q
Pharmacogenomics definition?
A
global analysis of how genes can influence pharmaceuticals
2
Q
2 kinds of DNA polymorphisms:
A
Germ line (inherited) Somatic (cancer)
3
Q
how would SNPs change protein structure/function? 2 ways.
A
- Direct
2. Alternative splicing
4
Q
Detection of polymorphisms: 2 ways:
A
- sequencing
2. microarrays
5
Q
what happens to someone who has a deficiency in TPMT re: 6 mercaptopurine prodrug?
A
too much active drug toxicity as there is no TPMT to balance it out
6
Q
3 ways that gene polymorphisms affect pharmacodynamics:
A
- receptors
- ion channels
- enzymes
7
Q
non-small cell lung cancer: what can be used to prodict success with gefitinib?
A
EGFR
