Pharmacogenomics Flashcards
1
Q
Name the three genetic variants that predict response of an individuals pharmacokinetics and dynamics.
A
Enzymes, transporters, receptors.
2
Q
When administering a drug that contains genetic information on the label, are clinicians required to perform genetic tests prior to administration?
A
No
3
Q
The two single nucleotide polymorphisms that can have an effect on how warfarin functions are _____ and _____.
A
CYP2C19 and VKORC1 (vitamin K dependent epoxide reductase).
4
Q
People who have diminished ______ enzyme activity would be less likely to experience a therapeutic response to the prodrug Clopidogrel.
A
CYP2C19
