Pharmacokinetics DLA

Question 1

What are the principles of pharmacokinetics?

Answer 1

Question 2

What are the mechanisms of drug permeation?

Answer 2

Question 3

What is absorption?

Answer 3

Question 4

What are the enteral routes?

Answer 4

Question 5

What are the parenteral routes?

Answer 5

Question 6

What are the nonenteral and non parenteral routes?

Answer 6

Question 7

What are the effects of pH on drug absorption?

Answer 7

Question 8

What is ion trapping?

Answer 8

Question 9

How does surface area affect drug absorption?

Answer 9

Question 10

How does blood flow affect absorption?

Answer 10

Question 11

How does contact time affect absorption?

Answer 11

Question 12

What’s the importance of P-glycoproteins?

Answer 12

Question 13

What is bioavailability and how do we calculate it?

Answer 13

Question 14

Discuss drug formulation

Answer 14

Question 15

How does chemical instability affect bioavailability?

Answer 15

Question 16

Describe how food and drug interactions affect bioavailability

Answer 16

Question 17

How does first pass hepatic metabolism have an affect on bioavailability ?

Answer 17

Question 18

How does drug liposolubility affect drug bioavailability ?

Answer 18

Question 19

What are the two main mechanisms of drug elimination?

Answer 19

• Metabolism of liver

- unchanged drug by kidneys

Question 20

Describe the metabolism of drugs

Answer 20

Question 21

Describe phase 1 of reactions of drugs metabolism

Answer 21

Question 22

Describe pharmaceutical equivalence and bioequivalence

Answer 22

Question 23

Describe phase II pharmaceutical drug reactions of drug metabolism

Answer 23

Question 24

What are the sites of drug metabolism?

Answer 24

Question 25

How do drugs bind to plasma proteins?

Answer 25

Question 26

How do drugs bind to tissues?

Answer 26

Question 27

What enzyme is pivotal to phase 1 drug metabolism?

Answer 27

Question 28

How important are human P450?

Answer 28

Question 29

What are the molecular mechanisms P450?

Answer 29

Question 30

What are the clinical consequences of cytochrome P450 induction?

Answer 30

Question 31

What are the mechanisms and consequences of P450 inhibition?

Answer 31

Question 32

What’s the impact of P-glycoprotein on drug transport?

Answer 32

Question 33

How does toxic metabolism affect P450?

Answer 33

Question 34

What are the genetic factors of drug metabolism?

Answer 34

Question 35

What are the roles of diet & environment on drug metabolism?

Answer 35

Question 36

How is drug metabolism affected by age?

Answer 36

Question 37

How is drug metabolism affected by diseases?

Answer 37

Question 38

How can drugs be excreted?

Answer 38

Question 39

Describe renal excretion of drugs

Answer 39

Question 40

Describe biliary excretion

Answer 40