Pharmacological Manipulation of the Cycle Flashcards
Name the reasons why we would like to manipulate the Estrous Cycle:
- Induction of Estrus
- Synchronization of Estrus / Ovulation
- Prevention of Estrus/Induction of Anestrus
Is a “natural” Prostaglandin F2-alpha drug (only IM injections)
Dinoprost (Lutalyse)
Extra-label use: Synthetic PGF-2alpha (Not FDA-approved for horses)
Cloprostenol (Estrumate)
Info. Slide
In large animal species, a single shot of Prostaglandin F2-alpha is only going to be effective in mature CL (wait for > 5 days post ovulation). It is going to short cycle with single shot.
(T/F) PGF will initiate cyclicity
False
(T/F) PGF destroys the CL and progesterone declines
True
In what species is PGF used to aid the treatment of pyometra (Cervix must be open & may cause nausea)?
Dogs
What hormone is the following describing:
- Commonly used to induce uterine contraction
- Rapid onset (1 min) of action and last 45 min
- No effect on the CL function
- Preferred ecbolic post-ovulation
Oxytocin
a difficult birth, typically caused by a large or awkwardly positioned fetus, by the smallness of the maternal pelvis, or by the failure of the uterus and cervix to contract and expand normally
Dystocia
What can be used for dog dystocia?
Oxytocin*
*must assure that there is no physical obstruction or disproportional size of fetus
What is the only approved Deslorelin in the US?
Sucromate (Bioniche Animal Health)
In horses, OV is expected in 40-42 hours
When are you using Progestogens?
- Extend Luteal Phase (Prevent Estrus)
- Pregnancy Maintenance
- Estrus Suppression/Synchronization
- Hasten first Ovulation of the Year
What is the most common Progestogen drug?
Altrenogest
- Given orally
- Does not cross-react with the P4 assay
Following the administration of prostaglandin F2alpha into a female during diestrus, you would expect the serum concentration of progesterone to (1) _____________. This results from a direct action of prostaglandin F2alpha on the (2) ____________________.
- decrease
- corpus luteum
A client brings a bitch that has helped 9 puppies at home and then stopped the uterine contractions. She still has two more puppies, so you decide to treat her medically with an ecbolic and administer a dose of:
Oxytocin
