Flashcards in Pharmacology Deck (107)
What are the 5 key elements in pharmacotherapeutics?
What pharmacologic principle are drug and dose based on?
disease targets and drugregulation
What pharmacologic principle are route and frequency based on?
route - AD
frequency - ME
What pharmacologic principle is duration based on?
What are 4 basic drug categories?
2. controlled substances
4. Dietary supplements
What phase is clinical testing starts comparing drugs to placebos or existing treatments?
What phase of clinical testing do most drugs fail?
What phase of clinical testing do you monitor "does it work?"
Phase II and III
If you have a drug similar to one that is already approved, what application do you use to bypass testing trials?
abbreviated new drug application (ANDA)
Do structure/function claims require FDA approval?
No, but needs a disclaimer.
only health claims do require FDA approval
What are the 3 different FDA categories of drug equivalency?
1. pharmaceutical equivalents
3. therapeutic equivalent
What does signa or "sig" indicate on a prescription pad?
drug directions to pts.
aka dosage regimen
Manufacturer distribution of depressants and stimulants are divided into 5 ______
The 5 schedules I-V are in order from (lower to higher) abuse potential or (higher to lower) abuse potential
higher to lower abuse potential
Schedule I - no medical use, high abuse potential
How many mg make 1 grain?
65 mg = 1 grain
How many grams make 1 ounce?
28.4g = 1 oz
how many grams in 1 lb?
454g = 1 lb
how many ml make 1 tsp?
5 ml = 1 tsp
how many ml make 1 tablespoon?
15ml = 1 tablespoon
how many ml make 1 oz?
30ml = 1 oz
What does od* and os stand for?
right eye, left eye
What is the relationship between Cp and Vd?
more drug in plasma = less being distributed
Higher volume of distribution = more/less lipid soluble drug?
more lipid soluble
drug formulations must be more hydrophilic/hydrophobic to dissolve and release molecule?
drug molecule must be more lipophilic/lipophobic to cross membrane?
after drug gets metabolized by liver it becomes more/less water soluble?
more water soluble
The more unionized a drug, the more/less lipid soluble it is.
More unionized = more lipid soluble
P-glycoproteins move drugs from the _______ space to the ______ space
Bioavailability is termined by comparing AUC following single/multiple dose of a drug following IV route?