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Flashcards in Pharmacology Deck (107)
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1

What are the 5 key elements in pharmacotherapeutics?

1. drug
2. dose
3. route
4. frequency
5. duration

2

What pharmacologic principle are drug and dose based on?

Pharmacodynamics -
disease targets and drugregulation

3

What pharmacologic principle are route and frequency based on?

Pharmacokinetics

route - AD
frequency - ME

4

What pharmacologic principle is duration based on?

Disease pathophysiology

5

What are 4 basic drug categories?

1. prescriptions
2. controlled substances
3. OTC
4. Dietary supplements

6

What phase is clinical testing starts comparing drugs to placebos or existing treatments?

Phase II

7

What phase of clinical testing do most drugs fail?

Phase III

8

What phase of clinical testing do you monitor "does it work?"

Phase II and III

9

If you have a drug similar to one that is already approved, what application do you use to bypass testing trials?

abbreviated new drug application (ANDA)

10

Do structure/function claims require FDA approval?

No, but needs a disclaimer.

only health claims do require FDA approval

11

What are the 3 different FDA categories of drug equivalency?

1. pharmaceutical equivalents
2. bioequivalent
3. therapeutic equivalent

12

What does signa or "sig" indicate on a prescription pad?

drug directions to pts.
aka dosage regimen

13

Manufacturer distribution of depressants and stimulants are divided into 5 ______

schedules

14

The 5 schedules I-V are in order from (lower to higher) abuse potential or (higher to lower) abuse potential

higher to lower abuse potential

Schedule I - no medical use, high abuse potential

15

How many mg make 1 grain?

65 mg = 1 grain

16

How many grams make 1 ounce?

28.4g = 1 oz

17

how many grams in 1 lb?

454g = 1 lb

18

how many ml make 1 tsp?

5 ml = 1 tsp

19

how many ml make 1 tablespoon?

15ml = 1 tablespoon

20

how many ml make 1 oz?

30ml = 1 oz

21

What does od* and os stand for?

right eye, left eye

22

What is the relationship between Cp and Vd?

inverse

more drug in plasma = less being distributed

23

Higher volume of distribution = more/less lipid soluble drug?

more lipid soluble

24

drug formulations must be more hydrophilic/hydrophobic to dissolve and release molecule?

hydrophilic

25

drug molecule must be more lipophilic/lipophobic to cross membrane?

lipophilic

26

after drug gets metabolized by liver it becomes more/less water soluble?

more water soluble

27

The more unionized a drug, the more/less lipid soluble it is.

More

More unionized = more lipid soluble

28

P-glycoproteins move drugs from the _______ space to the ______ space

intracellular, extracellular

(Inside-> out)

29

Bioavailability is termined by comparing AUC following single/multiple dose of a drug following IV route?

single

30

What is another word for extravascular?

Interstitial