pharmacology 37-antivirals Flashcards Preview

LECOM S3 PBL > pharmacology 37-antivirals > Flashcards

Flashcards in pharmacology 37-antivirals Deck (44):
1

what receptor does Maraviroc block

CCR5

2

how does Enfuviritide block HIV attachment and entry

inhibiting gp41-mediated fusion of HIV envelope with the host plasma membrane

3

what are the major adverse effects of Maraviroc

hepatotoxicity, MI/ischemia

4

what does Enfuviritide mimic

HR2

5

what are the major common adverse effects of Enfuviritide

gullain-barre syndrome, 6th nerve palsy

6

how must enfuviritide be administered

parenterally

7

what is the role of M2 with influenza infection

acidifies the interior of the virus

8

what is amantadine used to treat

influenza A AND parkinsonism

9

what is rimantadine used for the treatment of

influenza A

10

what phosphorylates cidofovir

cellular enzymes

11

what ads the first phosphate to acyclovir

viral thymidine kinase

12

what is the prodrug of acyclovir that has greater oral bioavailability

valacyclovir

13

when can renal failure occur when using acyclovir or valacyclovir

when it is IV administration

14

what is the major adverse effects associated with penciclovir and famciclovir

erythema multiform, GI disturbances, headache

15

what is the prodrug analogue of penciclovir

famciclovir

16

what is ganciclovir and valganciclovir used to treat

CMV

17

what are the major adverse effects of ganciclovir and valganciclovir

neutropenia, thrombocytopenia, anemia

18

what are the contraindications for ganciclovir and valganciclovir use

severe neutropenia and/or thrombocytopenia

19

what is the structure of acyclovir

guanine based attached to a broken and incomplete sugar ring

20

what does cidofovir mimic

deoxycytidine monophosphate

21

what drug prevents maternal-fetal HIV transmission

AZT

22

what is trifluridine used as

ophthalmic prepration

23

what anti-HIV -HBV nucleoside and nucleotide analogues are thymidine analogs

zidovudine and stavudine

24

what is the dose-limiting adverse effect of zidovudine (AZT)

hepatotoxicity

25

what drug used for anti-HIV -HBV nucleoside and nucleotide analogues can cause fatal hypersensitivity

abacavir

26

what is the toxicity of anti-HIV -HBV nucleoside and nucleotide analogues mostly due to

inhibition of mitochondrial DNA polymerase by drug triphosphate

27

what is a major adverse effect of tenofovir

can cause falcon syndrome

28

what is a major adverse effect of adefovir

renal toxicity

29

what is the major dose-limiting toxicity of fascarnet

renal impairment

30

what does resistance against raltegravir result from

point mutations

31

what does raltegravir inhibit

inhibits integrase (involved in HIV)

32

what inhibitor of viral integration can cause numbness around mouth and altered taste sensation

ritonavir

33

what is the prodrug form of amprenavir that has greater oral bioavailability

fosamprenavir

34

what is the action of influenza virus neuraminidase

cleaves silica acid from membrane glycoproteins

35

what is zanamivir and oseltamivir used to treat

influenza A and B

36

how is zanamivir administered

inhaler

37

what does fomivirsen bind to

mRNA that encodes iE2 (regulatory protein of CMV)

38

what is the clinical application of fomivirsen

CMV retinitis (second-line)

39

what is the contraindication for fomivirsen use

IV or intravitreal cidofovir therapy within 2-4 weeks, due to risk for exaggerated ocular inflammation

40

what is ribavirin used for the treatment of

respiratory syncytial virus (RSV), HCV (in combination with interferon-alpha)

41

what does ribavirin inhibit

inosine monophosphate dehydrogenase, leading to lower cellular GTP levels

42

how is ribavirin administered for treatment of RSV

aerosol form

43

what is docosanol used for the treatment of

topical treatment for HSV

44

what TLRs does imiquimod interfere with

TLR-7 and TLR-8 to boost innate immunity