Pharmacology - Anti-Anemia and Hematopoietic Stimulating Drugs

Question 1

Which of the following participate in the process of erythropoiesis?

(a) iron
(b) folate (vitamin B9)
(c) vitamin B12 (cobalamin)
(d) folate (vitamin B9) and vitamin B12 (cobalamin)
(e) iron and folate (vitamin B9) and vitamin B12 (cobalamin)

Answer 1

(e) iron and folate (vitamin B9) and vitamin B12 (cobalamin)

Question 2

Which medication(s) could be useful for treating sickle cell anemia?

(a) erythropoietin
(b) hydroxyurea
(c) iron
(d) erythropoietin and hydroxyurea
(e) erythropoietin and hydroxyurea and iron

Answer 2

(d) erythropoietin and hydroxyurea

Question 3

Deferoxamine may be a beneficial treatment for decreasing the side effects of transfusion therapy in which of the following types of anemia?

(a) sickle cell anemia
(b) iron deficiency anemia
(c) beta thalassemia
(d) sickle cell anemia and beta thalassemia
(e) sickle cell anemia and iron deficiency anemia

Answer 3

(d) sickle cell anemia and beta thalassemia

Question 4

Prior to endodontic treatment of Ms. Smith (age 75), you note an abnormal flag on her laboratory report indicating an erythrocyte MCV value of 115 fL. She mentions that she has had a problem with her blood before but can’t remember what it was or what she took for it. She has also been experiencing increased incidences of pain in her hands and feet, and difficulty walking. She is not diabetic.

You suspect a nutritional deficiency of some sort. What should be highest on your list
of differential diagnoses?

(a) macrocytic folate (vitamin B9) deficient anemia
(b) iron deficiency anemia
(c) porphyria
(d) microcytic vitamin B12 deficiency anemia
(e) macrocytic vitamin B12 deficiency anemia

Answer 4

(e) macrocytic vitamin B12 deficiency anemia

Question 5

In sickle cell anemia patients, which of the following medications is the most useful adjunctive medication for increasing hemoglobin F levels?

(a) deferoxamine
(b) iron
(c) hydroxyurea
(d) heme
(e) stem cell factor

Answer 5

(c) hydroxyurea

Question 6

Erythrocyte transfusion therapy can be used for which type of anemia?

(a) sickle cell
(b) iron deficiency
(c) B12 deficiency
(d) thalassemia
(e) sickle cell, iron deficiency and thalassemia-based anemias

Answer 6

(e) sickle cell, iron deficiency and thalassemia-based anemias

Question 7

Both vitamin B12 deficiency and Acute Intermittent Porphyria are associated with which of the following findings?

(a) MCV < 80 fL
(b) iron deficiency
(c) antibodies to intrinsic factor
(d) neurologic symptoms
(e) Plumer-Vinson Syndrome

Answer 7

(d) neurologic symptoms

Question 8

Which of the following growth factors is used to treat neutropenia?

(a) G-CSF
(b) IL-2
(c) IL3
(d) TPO
(e) IL-11

Answer 8

(a) G-CSF

Question 9

Which of the following growth factors is used to treat thrombocytopenia?

(a) SCF
(b) IL-2
(c) GM-CSF
(d) TPO
(e) G-CSF

Answer 9

(d) TPO

Question 10

Which growth factor, while not commonly used, may increase survival of bone marrow transplant patients with disseminated
candidiasis?

(a) SCF
(b) IL-2
(c) M-CSF
(d) TPO
(e) G-CSF

Answer 10

(c) M-CSF