Pharmacology (Beta-Blockers)

Question 1

Atenolol (Tenormin) Class and MOA

Answer 1

Beta-blocker: Cardioselective

Selective for B1 receptros on heart

MOA

• Neg inotrope
• Neg chronotrope
• Decr PVR by decr renin
• Block NE

Question 2

Metoprolol (Lopressor, Toprol XL) Class and MOA

Answer 2

Beta-blocker: Cardioselective

Selective for B1 receptros on heart

MOA

• Neg inotrope
• Neg chronotrope
• Decr PVR by decr renin
• Block NE

Question 3

Beta-Blocker (Cardioselective) Indication

Answer 3

First Line- CAD/ post-MI w/ ACEI/ARB

First Line- HF w/ ACEI/ARB + AA

Second Line- HTN, angina pectoris, a-fib/a-flutter

Question 4

Beta-Blocker (Cardiodselective) Contraindications

Answer 4

COPD/Asthma

Second or Third degree AV block

Severe decompensated HF

Caution in: depression, DM, PVD

Pregnancy

Question 5

Beta-Blocker Side Effects

Answer 5

Hypotension

Bradycardia

Can worsen depression

AV block

Fatigue

Masks signs of hypoglycemia (all but sweating)

Hyperlipidemia (not carvedilol)

Diabetes

Sexual dysfunction

SOB

Feeling cold

Question 6

Carvedilol (Coreg, Coreg CR) Class and MOA

Answer 6

Beta-Blocker: Vasodilating Nonselective

Targets B1 and A1 receptors

MOA

• Neg inotrope
• Neg chronotrope
• Decr PVR by decr renin

Question 7

Labetalol Class and MOA

Answer 7

Beta-Blocker: Vasodilating Nonselective

Targets B1 and A1 receptors

MOA

• Neg inotrope
• Neg chronotrope
• Decr PVR by decr renin

Question 8

Indication for Labetalol

Answer 8

HTN in Pregnancy

Hypertensive emergency/urgency

Question 9

Propanolol Class and MOA

Answer 9

Beta-Blocker: Noncardioselective

Blocks B1 and B2

MOA

• Neg inotrope
• Neg chronotrope
• Decr portal pressure through splnchnic vasocontriction

Question 10

Indication for propanolol

Answer 10

Essential tremor

HTN

migraine prophylaxis

Pheochromotoma

SVT, tachyarrythmias

Stable angina