pharmacology chapter 34: bacterial cell wall synthesis Flashcards Preview

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Flashcards in pharmacology chapter 34: bacterial cell wall synthesis Deck (37):
1

what 3rd generation cephalosporin is used for treatment of R. aeruginosa

ceftazidime

2

what are major adverse effects to ethambutol

optic neuritis, scotomas

3

what other things does bacitracin need to work

needs zinc or magnesium

4

what is cycloserine used for the treatment of

M. tuberculosis and MAC

5

what are first generation cephalosporins primarily used for

gram positives

6

where type of infections are cefotetan and cefoxitin primarily used for

intra-abdominal and pelvic infections

7

what is the mechanism of action of fosfomycin and fosmidomycin

inhibition production of murein monomers by inhibiting synthesis of UDP-NAM from UDP-NAG (inhibits MurA)

8

what does cycloserine inhibit the hepatic metabolism of

phenytoin

9

what type of medicine are most patients allergic to that are given aztreonam

penicillin

10

what is penicillin can treat against invasive enterococcal infections and listeria meningitis

ampicillin

11

what co-administration can lead to decreased absorption of fosmidomycin and fosfomycin

antacids and motility agents

11

what are the adverse effects of cycloserin

seizures, peripheral neuropathy

13

what is cycloserine a structural analog of

D-Ala

13

what is a major contraindication of cycloserine

epilepsy

16

what are the contraindications for using pyrazinamide

acute gout, severe hepatic dysfunction

17

what type of bacteria is aztreonam used for

gram negative (NO positive coverage)

18

what are the second generation cephalosporins

cefuroxime, cefotetan, cefoxitin

20

what is the major contraindication for using isoniazid or ethionamide

acute liver disease

21

what class of cephalosporins have the highest CNS penetration

3rd

22

what does isoniazid inhibit

FAS2

23

what is the major adverse effect of cefepime

may produce erythrocyte autoantibodies without significant hemolysis

25

what are the major adverse effects of using pyrazinamide

hepatotoxicity, arthralgia, hyperuricemia

26

how is telavancin administered

IV only

28

what is the mechanism of action of bacitracin

inhibits dephospho rylation of bactoprenyl diphosphate

29

what 3rd generation cephalosporin is primarily used for treatment of H. influenza

cefotaxime

30

what does pyrazinamide inhibit

FAS1

31

what type of bacteria is cefepime mostly used for

gram positive

32

what drugs can cause red man syndrome

vancomycin

32

what are the first generation cephalosporins

cefazolin and cephalexin

33

how are penicillin G and V administered

G via IV; V via oral

33

what generation is cefepime

4th

34

what are fosmidomycin and fosfomycin used for the treatment of

gram negative UTIs (E. coli, klebsiella, sebratia, clostridia

34

what is the mechanism of action of daptomycin

integrates into gram positive bacterial membrane, leading to formation of pores that cause potassium efflux, membrane depolarization and cell death

36

what does ethionamide inhibit

arabinosyl transferase

37

when is the nephrotoxicity increased with use of vancomycin

with ahminoglycosides

37

what cephalosporins can be used as surgical prophylaxis

cephalexin, cefazolin

37

what drug should daptomycin not be co-administered with

statins