Pharmacology of the Male Reproductive System

Question 1

What are adverse effects of gonadorelin?(3-7 points) Is this drug more tolerated in adults or children?

Answer 1

headache, flushing, nausea and hypersensitivity reactions like bronchospasm and anaphylaxis; it is more tolerated in children with temporary exacerbation of precocious puberty

Question 1

What GnRH antagonist is not indicated in women because it cause birth defects?

Answer 1

Abarelix

Question 1

Androgen replacement therapy is not used in what type of patients until puberty?

Answer 1

hypopituitarism patients

Question 2

What is a clinical use for DHEA?

Answer 2

weight loss

Question 3

What are adverse side effects of exogenous androgens?(3-6 points)

Answer 3

azoospermia, virilization of males and females in children and women; stimulation of prostatic hyperplasia; salt and water retention due to mineralcorticoid like activity; cholestatis jaundice; masculinization of female fetus; acne; sleep apnea; gynecomastia due to aromitization of testosterone in peripheral tissues

Question 4

What is the generic name for the drug synarel?

Answer 4

Nafareiln

Question 4

What androgens are orally active when given by mouth?(2 poins)

Answer 4

methyltestosterone and fluoxymeseterone

Question 5

What general type of drug is nilutamide?

Answer 5

antagonist & inhibitor of androgens

Question 6

How do you administered anabolic steroids?(3 points)

Answer 6

orally, paranterally or patch

Question 7

How do you administered leuprolide?(3 points) It is used to treat what disease?(1-2 points)

Answer 7

you can administered leuprolide IV, SC and IM. It is used to treat prostate carcinoma and central precocious puberty in boys before the age of 9YO

Question 8

What general type of drug is bicalutamide?

Answer 8

antagonist & inhibitor of androgens

Question 9

Sprinolactone is an aldosterone antagonist that could be used to treat what endocrine disorder?

Answer 9

hirsutism in women

Question 10

What are side effects of menotropin(hMG)?(2-4 points)

Answer 10

thromboembolism, atelectasis, ARDS, gynecomastia in man

Question 11

How do you administered GnRH agonist?

Answer 11

intravaneously, subcutaneously and intramuscularly

Question 12

What drug is a human menopausal gonatropin? It has both FSH-LH like properties?

Answer 12

Menotropin

Question 13

What are adverse reactions caused by GnRH antagonist?(3-6 points)

Answer 13

allergic reactions, nausea and vomiting, vaginal bleeding, abdominal pain, dark urine, yellowing of skin, liver

Question 14

What is the generic name for Factrel?

Answer 14

Gonadorelin

Question 16

How do you administered Nafarelin? What disease is it used to treat?

Answer 16

nasal spray; precocious puberty

Question 17

What type of drug is Degarelix?

Answer 17

GnRH antagonist

Question 18

What type of drug is Ganirelix?

Answer 18

GnRH antagonist

Question 19

What type of drug is Cetrorelix?

Answer 19

GnRH antagonist

Question 21

How do you administered Goserelin and HIstrelin? What disease do they treat? What is the mechanism of action of these drugs?

Answer 21

Implants; prostate cancer; they all surpress the secretion of LH and FSH resulting in a decrease testosterone and estrogen levels

Question 21

What are examples of drugs that increase gonadotropin secretion?(2-3 points)

Answer 21

Ketoconazole, chemotherapy and opiate antagonists

Question 22

What is the generic name for the drug Lupron?

Answer 22

Leuprolide

Question 23

What type of injection into the lesions of patients with AIDS-related Kaposi's sarcoma cause regression in a dose related manner

Answer 23

hCG injection

Question 25

What are side effects of hCG?(3-6 points)

Answer 25

headache, depression, edema, precocious puberty, gynecomastia, production of antibodies to hCG(rarely)

Question 26

What general type of drug is Nilutamide?

Answer 26

antagonists & inihibitor of androgens

Question 27

Is testosterone orally active when given by mouth?

Answer 27

no

Question 28

What general type of drug is flutamide?

Answer 28

a non-selective inhibitor of androgens

Question 29

What type of drug is Aberelix?

Answer 29

GnRH anatonigst

Question 31

Where does degradation of GnRH agonist take place?

Answer 31

hypothalamus and pituitary

Question 32

Low DHEA levels has been associated with development of what type of cancers?(2 points)

Answer 32

gastric and bladder cancers

Question 33

Exogenous androgens are contraindicated in what group?(2-4 points)

Answer 33

patients with carcinoma of the prostate; patients with carcinoma of the breast; developing children and infants; patient with renal or cardiac disease; methytestosterone therapy is associated with creatinuria

Question 34

What general type of drug is finasteride?

Answer 34

antagonist & inhibitor of androgens

Question 35

What type of analog is Gonadorelin? This drug is used diagnostically for what type of treatment?(3 points) What are the therapeutic uses?(2 points)

Answer 35

GnRH analog; prepubertal hypogonadotropic hypogonadism; the drug could be given in a pulsatile fashion to treat infertility caused by hypothalamic hypogonadotropin hypogonadism; this could could be given to treat infertility caused by hypothalamic hypogonadotropic hypogonadism or use in a continuous fashion to treat prostate cancer and precocious puberty

Question 36

What drugs are known to decrease gonadotropin secretion?(3-8 points)

Answer 36

verapamil, estsrogens, androgens, opiates, dopamine, bromocriptine, glucocorticoids, digitoxin