Pharmacology of the Skin Flashcards Preview

Dermatology week 1 > Pharmacology of the Skin > Flashcards

Flashcards in Pharmacology of the Skin Deck (12)
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1

Brief explanation of topical treatment

Largely for local treatment but also treats underlying tissues

2

What is the most important layer when it comes to drug penetration

The keratin layer

3

What holds together adjacent corneocytes

Corneodesmosomes

4

Treatment for itching

Antihistamins

5

Treatment for warts

Keratolytic agents

6

Three modes of action with glucocorticoids

Anti-inflammatory, immunosuppressant and vasoconstrcting

7

Is 1% hydrocortisone acetate a mild or potent corticosteroid

Mild

8

Is 0.1% hydrocortisone butyrate a mild or potent corticosteroid

Potent

9

6 side effects of high potency steroid

Skin atrophy, systemic effect, spread of infection, steroid rosacea, stretch marks and small superficial dilated blood vessels

10

Explain the procedure of subcutaneous route of administration

Needle is inserted into fatty adipose tissue just beneath the skin surface

11

Do high or low molecular weight compounds tend to enter systemically via the lymphatics

High molecular weight compounds

12

List 4 criteria(ish) for transdermal drug delivery

Low molecular weight
Moderately lipophilic
Potent
Relatively brief half life