Molecular basis of Bacterial Virulence Flashcards Preview

Dermatology week 1 > Molecular basis of Bacterial Virulence > Flashcards

Flashcards in Molecular basis of Bacterial Virulence Deck (13)
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1

What are virulence factors

Molecules produced by pathogens that add to their effectiveness

2

What is virulence

Capacity of a microbe to do damage

3

What does adhesin do

Enables binding of the organism to host tissue

4

What does invasin do

Enables organism to invade a host cell/tissue

5

What does impedin

Enables organism to avoid host defense mechanisms

6

What does aggressin do

Causes damage to host directly

7

What does modulin do

Induced damage to host directly

8

What is TSST

A superantigen that causes toxic shock syndrome

9

What is the effect of superantigens on cyotkines and the immune system

Causes a massive release of cytokines and inappropriate immune response

10

Diagnostic criteria for toxic shock syndrome

Fever of 39 or over
A sunburn like rash on palms and/or soles
Hypotension
More that 3 organ systems involved

11

Examples of GAS skin conditions

Impetigo and cellulitis

12

Describe impetigo

Highly contageous through contact with discharge on face. Infection immediately below the surface

13

Describe cellulitis

Deeper skin infection in the dermis