Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Module 1 > pharmacology quiz 2 > Flashcards

pharmacology quiz 2 Flashcards

1
Q

pharmacokinetics

A

the motion/movement of drugs in your body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

pharmacokinetics process

A

absorption
distribution
metabolism
excretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

absorption

A

the movement of a drug from its site of administration into the blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

the rate of absorption determines ____

A

how soon the effects will take place

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

the amount of drug determines ____

A

how intense the effects will be

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

factors affecting absorption process (6)

A

-rate of dissolution
-surface area
-blood flow
-lipid solubility
-pH partitioning
-route of administration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

routes of administration (2)

A

enteral (GI tract)
parenteral (outside GI tract)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

enteral (GI tract)

A

oral (by mouth/PO)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

parenteral (outside GI tract)

A

Intravenous (IV)
subcutaneous (subQ)
intramuscular (IM)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

oral, by mouth, PO barriers to absorption

A

epithelial lining of GI tract

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

oral absorption patterns

A

slow and variable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

advantages of PO meds (3)

A

-safer than injections
-ideal for self administration
-easy,convenient, cheap

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

disadvantages of PO meds (4)

A

-GI irritation
-requires cooperative pt
-inactivation
-variability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

intravenous (IV) barriers to absorption

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

IV absorption pattern

A

instantaneous and complete

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

advantages of IV (4)

A

-rapid onset
-control
-permits use of large fluid volumes
-permits use of irritant drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

disadvantages of IV (4)

A

-high cost, difficulty, inconvenience
-irreversibility
-infection
-high risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

intramuscular (IM) and subcutaneous (subQ) barriers to absorption

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

IM and SubQ absorption pattern

A

VARIABLE
-water solubility
-blood flow

20
Q

advantages of IM and SubQ (2)

A

-can be used for poorly soluble drugs
-can be used for depot preparations

21
Q

disadvantages of IM and subQ (4)

A

-discomfort
-inconvenience
-can cause muscle and nerve injury with improper technique
-bleeding risk

22
Q

when parenteral administration is preferred: (6)

A

-emergencies
-situations requiring tight control
-GI incompatibility
-treatment with drugs that cannot cross membranes
-condition better treated with long-acting preparation
-pts who cannot or will not take oral preparation

23
Q

distribution

A

the movement of drugs throughout the body

24
Q

distribution process

A

-blood flow to tissues
-drug’s ability to enter cells
-drug’s ability to exit the vascular system

25
Q

drug metabolism

A

the enzymatic alteration of drug structure to a more water-soluble form that can be excreted

26
Q

special factors/considerations in drug metabolism

A

-age
-first-pass effect
-nutritional status
-competition between drugs

27
Q

excretion

A

the removal of drugs from the body

28
Q

excretion routes

A

-bile
-urine/feces
-sweat/saliva
-breast milk
-expired air

29
Q

monitoring of drug responses
plasma drug levels

A

correlation between response to drug and level in plasma

30
Q

monitoring of drug responses
two important levels

A

-minimum effective concentration (MEC)
-toxic concentration

31
Q

monitoring of drug responses
therapeutic range

A

determines whether the drug can be safely given

32
Q

monitoring of drug responses
drug half-life

A

determines dosing interval

33
Q

monitoring of drug responses
repeated dosing

A

determines rate and extent of accumulation

34
Q

peak

A

highest level of drug in the body, 1-2 hours after given

35
Q

trough

A

lowest level of drug in body, right before next dose

36
Q

maintenance

A

lower dose to maintain state of drug in body

37
Q

loading

A

higher dose to get response

38
Q

ED50

A

average effective dose

39
Q

LD50

A

lethal dose

40
Q

pharmacodynamics

A

the force or power of a drug

41
Q

drug drug interactions outcomes (3)

A

potentiate
inhibit
new response

42
Q

potentiate

A

intensifies the effects

43
Q

inhibit

A

reduce the effects

44
Q

new response

A

effect not seen with single drug alone

45
Q

drug v food (5)

A

-absorption
-drug metabolism
-drug toxicity
-drug action
-timing

Module 1 (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions